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Cancer immunotherapy approved in UK | Cancer immunotherapy approved in UK |
(about 17 hours later) | |
A pioneering cancer drug that harnesses the power of the immune system has been approved for use in the UK. | A pioneering cancer drug that harnesses the power of the immune system has been approved for use in the UK. |
Nivolumab was one of the drugs labelled a "milestone" therapy at a major cancer conference last month. | Nivolumab was one of the drugs labelled a "milestone" therapy at a major cancer conference last month. |
It has been approved for lung cancer through the UK's Early Access to Medicines Scheme and has been given an EU license for melanoma. | |
The drug has been shown to stop skin and lung cancers from progressing, in clinical trials. | The drug has been shown to stop skin and lung cancers from progressing, in clinical trials. |
Enhanced defence | Enhanced defence |
The immune system is a powerful defence against infection. However, there are many "brakes" built in to stop the system attacking its own tissues. | The immune system is a powerful defence against infection. However, there are many "brakes" built in to stop the system attacking its own tissues. |
Cancer - which is a corrupted version of healthy tissue - can take advantage of these brakes to evade assault from the immune system. | Cancer - which is a corrupted version of healthy tissue - can take advantage of these brakes to evade assault from the immune system. |
Nivolumab takes the brakes off. | Nivolumab takes the brakes off. |
One trial of nivolumab, alongside an already approved medicine ipilimumab, stopped melanoma advancing for nearly a year in 58% of patients. | One trial of nivolumab, alongside an already approved medicine ipilimumab, stopped melanoma advancing for nearly a year in 58% of patients. |
A separate trial in lung cancer showed the drug more than doubled survival times in some patients. | A separate trial in lung cancer showed the drug more than doubled survival times in some patients. |
The treatment has now been allowed in the UK for both skin and lung cancers. | |
Gill Nuttall, from Melanoma UK, said: "There has been an alarming rise in the number of cases of melanoma in the UK over recent years. | Gill Nuttall, from Melanoma UK, said: "There has been an alarming rise in the number of cases of melanoma in the UK over recent years. |
"Today's news is therefore very welcome as it provides more options for patients and the potential of better, longer survival." | "Today's news is therefore very welcome as it provides more options for patients and the potential of better, longer survival." |
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