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Key gene work scoops Nobel Prize Key gene work scoops Nobel Prize
(10 minutes later)
Two US scientists and their UK collaborator have been awarded the Nobel Prize for medicine for their groundbreaking work in gene technology.Two US scientists and their UK collaborator have been awarded the Nobel Prize for medicine for their groundbreaking work in gene technology.
Mario Capecchi, Oliver Smithies and Briton Martin Evans developed a technique known as gene targeting.Mario Capecchi, Oliver Smithies and Briton Martin Evans developed a technique known as gene targeting.
It enabled them to replicate human diseases in mice by introducing genetic changes into the animal's stem cells.It enabled them to replicate human diseases in mice by introducing genetic changes into the animal's stem cells.
The Nobel Committee said this had led to many new insights into conditions such as cancer and heart disease.The Nobel Committee said this had led to many new insights into conditions such as cancer and heart disease.
For instance, science has gained a greater understanding of how disease can strike otherwise healthy people.For instance, science has gained a greater understanding of how disease can strike otherwise healthy people.
The technique has also helped to shed new light on the ageing process, and on how the embryo develops in the womb.The technique has also helped to shed new light on the ageing process, and on how the embryo develops in the womb.
In its citation, the Nobel Committee praised the technique as "an immensely powerful technology" which was now being used in virtually all areas of biomedical research.In its citation, the Nobel Committee praised the technique as "an immensely powerful technology" which was now being used in virtually all areas of biomedical research.
"Gene targeting in mice has pervaded all fields of biomedicine," it said."Gene targeting in mice has pervaded all fields of biomedicine," it said.
"Its impact on the understanding of gene function and its benefits to mankind will continue to increase over many years to come.""Its impact on the understanding of gene function and its benefits to mankind will continue to increase over many years to come."
Gene knockoutGene knockout
The technique is commonly described as gene "knockout".The technique is commonly described as gene "knockout".
It enables scientists to silence specific genes, and monitor the effect, so that gene-by-gene they are able to build a picture of the development of disease.It enables scientists to silence specific genes, and monitor the effect, so that gene-by-gene they are able to build a picture of the development of disease.
To date more than 10,000 mice genes - around half of the total - have been knocked out, with the rest confidently predicted to follow soon.To date more than 10,000 mice genes - around half of the total - have been knocked out, with the rest confidently predicted to follow soon.
As a result, more than 500 different mouse models of human disorders have been developed - including cardiovascular and neuro-degenerative diseases, diabetes and cancer.As a result, more than 500 different mouse models of human disorders have been developed - including cardiovascular and neuro-degenerative diseases, diabetes and cancer.
The three scientists will share the prestigious $1.54million award. All three scientists, who will share the prestigious $1.54million award, have subsequently used gene targetting to make significant advances.
Professor Capecchi, based at the University of Utah, has used the technology to uncover the role of genes involved in organ development, and the overall plan of the body.
Sir Martin, of the University of Cardiff, has specialised on the inherited disease cystic fibrosis.
Professor Smithies, of the University of North Carolina at Chapel Hill, was born in the UK, but has since taken US citizenship.
He has developed mouse models for common human diseases such as high blood pressure and thickened arteries.