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| Mice 'can lose innate fear of cats' | Mice 'can lose innate fear of cats' |
| (about 3 hours later) | |
| Mice may permanently lose their innate fear of cats after they have been infected with a microscopic parasite, researchers say. | |
| The single-celled Toxoplasma gondii parasite is already known to inhibit their hard-wired fear of cats. | The single-celled Toxoplasma gondii parasite is already known to inhibit their hard-wired fear of cats. |
| But even after they were cleared of the infection, mice no longer reacted with fear to a bobcat's urine. | But even after they were cleared of the infection, mice no longer reacted with fear to a bobcat's urine. |
| The team, writing in the journal Plos One, says the infection could cause a permanent change to their brains. | The team, writing in the journal Plos One, says the infection could cause a permanent change to their brains. |
| Wendy Ingram and colleagues at the University of California, Berkeley, measured how mice reacted to a bobcat's urine. | Wendy Ingram and colleagues at the University of California, Berkeley, measured how mice reacted to a bobcat's urine. |
| Cats typically mark their territory with urine, which helps mice detect and avoid an area in which predators might lurk. | Cats typically mark their territory with urine, which helps mice detect and avoid an area in which predators might lurk. |
| Those that remained uninfected with Toxoplasma gondii showed an aversion to the urine, whereas those that were infected walked freely around the test area. | Those that remained uninfected with Toxoplasma gondii showed an aversion to the urine, whereas those that were infected walked freely around the test area. |
| "It is remarkable that even after the infection has been largely or completely cleared, a profound behavioural change persists," said Ms Ingram. | "It is remarkable that even after the infection has been largely or completely cleared, a profound behavioural change persists," said Ms Ingram. |
| "Simply having a transient infection resulting in what is potentially a permanent change in host biology may have huge implications for infectious disease medicine." | "Simply having a transient infection resulting in what is potentially a permanent change in host biology may have huge implications for infectious disease medicine." |
| In rodents, the infection is usually contracted from eating cat faeces. The parasite then works itself into every organ in the body, especially the brain, where it forms cysts. | In rodents, the infection is usually contracted from eating cat faeces. The parasite then works itself into every organ in the body, especially the brain, where it forms cysts. |
| Pregnancy complications | Pregnancy complications |
| The infection can also be spread to humans, with recent estimates suggesting that 350,000 people a year contract toxoplasmosis. | The infection can also be spread to humans, with recent estimates suggesting that 350,000 people a year contract toxoplasmosis. |
| It can create serious complications in pregnancy and adversely affect people with already weakened immune systems. | It can create serious complications in pregnancy and adversely affect people with already weakened immune systems. |
| Ms Ingram told BBC News that the results highlight how current thinking on infectious disease may need to change. | Ms Ingram told BBC News that the results highlight how current thinking on infectious disease may need to change. |
| "Typically if you have a bacterial infection, you go to a doctor and take antibiotics and the infection is cleared and you expect all the symptoms to also go away. | "Typically if you have a bacterial infection, you go to a doctor and take antibiotics and the infection is cleared and you expect all the symptoms to also go away. |
| "Now we have an example where there is no obvious damage done by the parasite, yet major changes in the neurobiology of the mouse remains after the parasite is gone," she said. | "Now we have an example where there is no obvious damage done by the parasite, yet major changes in the neurobiology of the mouse remains after the parasite is gone," she said. |
| The way forward, she added, would be to look at all the antibodies present in a patient's blood. | The way forward, she added, would be to look at all the antibodies present in a patient's blood. |
| "This would show all the parasites and bacteria a person has ever been exposed to and may end up playing a bigger role in explaining illnesses." | "This would show all the parasites and bacteria a person has ever been exposed to and may end up playing a bigger role in explaining illnesses." |
| Joanne Webster at Imperial College London, who was not involved with the research, said the work was a valuable addition to the scientific literature on this subject. | Joanne Webster at Imperial College London, who was not involved with the research, said the work was a valuable addition to the scientific literature on this subject. |
| She said it could have important implications for humans, especially patients with personality disorders such as schizophrenia. | She said it could have important implications for humans, especially patients with personality disorders such as schizophrenia. |
| "It is very useful to know that these fatal feline attraction behavioural changes do appear to be hard-wired," Prof Webster added. | "It is very useful to know that these fatal feline attraction behavioural changes do appear to be hard-wired," Prof Webster added. |