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| Three-person IVF moves closer in UK | Three-person IVF moves closer in UK |
| (35 minutes later) | |
| The UK has moved closer to becoming the first country to allow the creation of babies from three people. | The UK has moved closer to becoming the first country to allow the creation of babies from three people. |
| The Human Fertilisation and Embryology Authority (HFEA) has advised the government that there is no evidence the advanced form of IVF is unsafe. | The Human Fertilisation and Embryology Authority (HFEA) has advised the government that there is no evidence the advanced form of IVF is unsafe. |
| The fertility regulator's public consultation also showed "general support" for the idea as the benefits outweighed the risks. | The fertility regulator's public consultation also showed "general support" for the idea as the benefits outweighed the risks. |
| A final decision on whether to press ahead rests with ministers. | A final decision on whether to press ahead rests with ministers. |
| If the techniques were approved it help a handful of families each year. Around one in 6,500 children develop serious "mitochondrial disorders" which are debilitating and fatal. | If the techniques were approved it help a handful of families each year. Around one in 6,500 children develop serious "mitochondrial disorders" which are debilitating and fatal. |
| Research suggests that using mitochondria from a donor egg can prevent the diseases. | Research suggests that using mitochondria from a donor egg can prevent the diseases. |
| However, it would result in babies having DNA from two parents and a tiny amount from a third donor. | However, it would result in babies having DNA from two parents and a tiny amount from a third donor. |
| Concerns have been raised both about the safety and the ethics of the techniques. | Concerns have been raised both about the safety and the ethics of the techniques. |
| The results of a public consultation at the end of 2012 showed there was support for the idea. | The results of a public consultation at the end of 2012 showed there was support for the idea. |
| Prof Neva Haites, who was on the expert panel supervising the consultation, said: "Broadly speaking the public was in favour of these novel techniques being translated into treatments. | Prof Neva Haites, who was on the expert panel supervising the consultation, said: "Broadly speaking the public was in favour of these novel techniques being translated into treatments. |
| "They felt that any ethical concerns were outweighed by potential benefits." | "They felt that any ethical concerns were outweighed by potential benefits." |
| One of the main issues raised was of a "slippery slope" which could lead to other forms of genetic modification. | One of the main issues raised was of a "slippery slope" which could lead to other forms of genetic modification. |
| 'Power stations' | 'Power stations' |
| Mitochondria are the tiny biological power stations that give energy to nearly every cell of the body. | Mitochondria are the tiny biological power stations that give energy to nearly every cell of the body. |
| Defects can leave the body starved of energy, resulting in muscle weakness, blindness, heart failure and death in the most extreme cases. | Defects can leave the body starved of energy, resulting in muscle weakness, blindness, heart failure and death in the most extreme cases. |
| The cigar-shaped mitochondria are passed only from mother to child. A father does not pass on his mitochondria through his sperm. | The cigar-shaped mitochondria are passed only from mother to child. A father does not pass on his mitochondria through his sperm. |
| Scientists have devised two techniques that allow them to take the genetic information from the mother and place it into the egg of a donor with healthy mitochondria. It is like taking two fried eggs and switching the yolks. | Scientists have devised two techniques that allow them to take the genetic information from the mother and place it into the egg of a donor with healthy mitochondria. It is like taking two fried eggs and switching the yolks. |
| How would it work? | How would it work? |
| However, this would create a baby with genetic information from three people, as mitochondria have their own genes in their own DNA. | However, this would create a baby with genetic information from three people, as mitochondria have their own genes in their own DNA. |
| The implications are not just for the couple and the child. If the therapy was performed it would have ramifications through the generations as scientists would be altering human genetic inheritance. | The implications are not just for the couple and the child. If the therapy was performed it would have ramifications through the generations as scientists would be altering human genetic inheritance. |
| 'Recommendations' | 'Recommendations' |
| The HFEA has advised that the any changes to the law should be only for the modification of mitochondria to overcome serious diseases and that there should still be a ban on changes to the main nuclear DNA, which contains the vast majority of a person's genetic code. | The HFEA has advised that the any changes to the law should be only for the modification of mitochondria to overcome serious diseases and that there should still be a ban on changes to the main nuclear DNA, which contains the vast majority of a person's genetic code. |
| It also recommended continuing research and that any children born through these techniques be monitored closely. | It also recommended continuing research and that any children born through these techniques be monitored closely. |
| There was vigorous discussion at the HFEA Open Meeting, where the advice to ministers was agreed, around issues of identification. In sperm and egg donation the donor is identified. | There was vigorous discussion at the HFEA Open Meeting, where the advice to ministers was agreed, around issues of identification. In sperm and egg donation the donor is identified. |
| The meeting agreed to advise ministers that there should be no right for the child to know the identity of the donor, however, the HFEA will tell ministers that the issue is finely balanced. | The meeting agreed to advise ministers that there should be no right for the child to know the identity of the donor, however, the HFEA will tell ministers that the issue is finely balanced. |
| Mr Hossam Abdalla, clinical director of the Lister Fertility Clinic in London, told the meeting: "If a child wants to know about that, why are we so restrictive... why are we telling them we they can't have this access?" | Mr Hossam Abdalla, clinical director of the Lister Fertility Clinic in London, told the meeting: "If a child wants to know about that, why are we so restrictive... why are we telling them we they can't have this access?" |
| Prof Lisa Jardine, chairwoman of the HFEA, said the UK was in one of the most advance positions in the world. | Prof Lisa Jardine, chairwoman of the HFEA, said the UK was in one of the most advance positions in the world. |
| "Other countries are astounded that we're this far on in the discussions," she said. | "Other countries are astounded that we're this far on in the discussions," she said. |
| However, she pointed out the techniques would be used only for mitochondrial disorders: "This is not a Rubicon or a slippery slope." | However, she pointed out the techniques would be used only for mitochondrial disorders: "This is not a Rubicon or a slippery slope." |
| Any time soon? | Any time soon? |
| These therapies using sperm and eggs from three people are not yet ready to be performed in the clinic. However, it is thought that scientists in the UK and the US are getting close to the point where it will be possible. | These therapies using sperm and eggs from three people are not yet ready to be performed in the clinic. However, it is thought that scientists in the UK and the US are getting close to the point where it will be possible. |
| Prof Robin Lovell-Badge, part of the expert panel analysing the science, said there was "still no evidence to suggest the techniques are unsafe," but he said further experiments were needed for reassurance. | Prof Robin Lovell-Badge, part of the expert panel analysing the science, said there was "still no evidence to suggest the techniques are unsafe," but he said further experiments were needed for reassurance. |
| "Safety is absolutely not a black and white issue. In reproductive medicine in particular it is not possible to be absolutely certain about the consequences of any new treatment until children are born. | "Safety is absolutely not a black and white issue. In reproductive medicine in particular it is not possible to be absolutely certain about the consequences of any new treatment until children are born. |
| "Someone at some point is going to have to take the brave decision to go ahead with it." | "Someone at some point is going to have to take the brave decision to go ahead with it." |
| One of the pioneers of the field, Prof Doug Turnbull, from Newcastle University, said: "The techniques we are working on could help hundreds of women have healthy children." | |
| He said more research was required, but it was now "crucial" that the government approved the techniques in the UK. | |
| The HFEA advice has been passed onto ministers. | |
| Making three-person IVF legal does not require a new act of Parliament, but would require a vote in both the Commons and the Lords. | Making three-person IVF legal does not require a new act of Parliament, but would require a vote in both the Commons and the Lords. |
| Speaking after the meeting Dr David King, the director of Human Genetics Alert, said: "Historians of the future will point to this as the moment when technocrats crossed the crucial line, the decision that led inexorably to the disaster of genetically engineered babies and consumer eugenics. | Speaking after the meeting Dr David King, the director of Human Genetics Alert, said: "Historians of the future will point to this as the moment when technocrats crossed the crucial line, the decision that led inexorably to the disaster of genetically engineered babies and consumer eugenics. |
| "This was the moment at which they casually tossed the bioethical consensus of the last 30 years into the trash. And for what? | "This was the moment at which they casually tossed the bioethical consensus of the last 30 years into the trash. And for what? |
| "Not so mothers could avoid having sick babies, because they could do that already, through egg donation. It was so that a few dozen mothers who insisted they must be genetically related to their child could be satisfied." | "Not so mothers could avoid having sick babies, because they could do that already, through egg donation. It was so that a few dozen mothers who insisted they must be genetically related to their child could be satisfied." |
| The Department of Health said mitochondrial diseases could have a "devastating impact" on families and it would consider the HFEA's advice. | The Department of Health said mitochondrial diseases could have a "devastating impact" on families and it would consider the HFEA's advice. |