This article is from the source 'bbc' and was first published or seen on . It will not be checked again for changes.
You can find the current article at its original source at http://news.bbc.co.uk/go/rss/-/1/hi/health/5404184.stm
The article has changed 6 times. There is an RSS feed of changes available.
| Version 2 | Version 3 |
|---|---|
| Treatment 'to neutralise all flu' | Treatment 'to neutralise all flu' |
| (20 minutes later) | |
| Scientists say they are developing an entirely new way of providing instant protection against flu. | Scientists say they are developing an entirely new way of providing instant protection against flu. |
| In preliminary tests, it was found to protect animals against various strains of the virus - and may also protect against future pandemic strains. | In preliminary tests, it was found to protect animals against various strains of the virus - and may also protect against future pandemic strains. |
| Warwick University researchers stripped a flu virus of some genetic material. | |
| This, they say, created a "protecting virus" which slows down the rate of infection so much that the flu virus effectively becomes its own vaccine. | This, they say, created a "protecting virus" which slows down the rate of infection so much that the flu virus effectively becomes its own vaccine. |
| That is to say, it works by giving the body time to mobilise its defences. They plan to develop the treatment as a nasal spray. | That is to say, it works by giving the body time to mobilise its defences. They plan to develop the treatment as a nasal spray. |
| Experts warned much more testing was required. | Experts warned much more testing was required. |
| This is cutting edge science, but there is a lot that could still go wrong Professor John Oxford | This is cutting edge science, but there is a lot that could still go wrong Professor John Oxford |
| However, they said the development of the vaccine was timely, amid concerns the H5N1 bird flu strain circulating in south east Asia could mutate into a pandemic strain which would put millions of lives at risk. | However, they said the development of the vaccine was timely, amid concerns the H5N1 bird flu strain circulating in south east Asia could mutate into a pandemic strain which would put millions of lives at risk. |
| Existing vaccination methods depend on stimulating the body's immune system, so that white blood cells produce antibodies that attach to the surface of the virus and start the process of killing it. | Existing vaccination methods depend on stimulating the body's immune system, so that white blood cells produce antibodies that attach to the surface of the virus and start the process of killing it. |
| This works well for many diseases, such as smallpox, polio and measles, but is much less effective with flu, as the coat of the flu virus is continually changing. | This works well for many diseases, such as smallpox, polio and measles, but is much less effective with flu, as the coat of the flu virus is continually changing. |
| Vaccination against one strain of flu is totally ineffective against another. | Vaccination against one strain of flu is totally ineffective against another. |
| Crowded out | Crowded out |
| Professor Nigel Dimmock has spent more than two decades developing the new approach. | Professor Nigel Dimmock has spent more than two decades developing the new approach. |
| To create the protecting virus he deleted around 80% of the genetic material of one of the eight RNA segments that make up the flu virus. | To create the protecting virus he deleted around 80% of the genetic material of one of the eight RNA segments that make up the flu virus. |
| This deletion makes the virus harmless and prevents it from reproducing by itself within a cell, so that it cannot spread like a normal influenza virus. | This deletion makes the virus harmless and prevents it from reproducing by itself within a cell, so that it cannot spread like a normal influenza virus. |
| However, if it is joined in the cell by another influenza virus, it retains its harmless nature but starts to reproduce - and at a much faster rate than the new influenza virus. | However, if it is joined in the cell by another influenza virus, it retains its harmless nature but starts to reproduce - and at a much faster rate than the new influenza virus. |
| This fast reproduction rate - spurred by the new flu infection - means that the new invading influenza is effectively crowded out. | This fast reproduction rate - spurred by the new flu infection - means that the new invading influenza is effectively crowded out. |
| This vastly slows the progress of the new infection, prevents flu symptoms, and gives the body time to develop an immune response to the harmful new invader. | This vastly slows the progress of the new infection, prevents flu symptoms, and gives the body time to develop an immune response to the harmful new invader. |
| One size fits all | One size fits all |
| The Warwick team believes its research indicates the protecting virus would have the same effect regardless of the strain of flu infection. | The Warwick team believes its research indicates the protecting virus would have the same effect regardless of the strain of flu infection. |
| This is because the coat of the virus is irrelevant to the protection process - the effect works on the virus genes inside the cell. | This is because the coat of the virus is irrelevant to the protection process - the effect works on the virus genes inside the cell. |
| In addition it protects instantly, whereas protection generated by conventional flu vaccination takes two to three weeks to become fully effective. | In addition it protects instantly, whereas protection generated by conventional flu vaccination takes two to three weeks to become fully effective. |
| Experiments so far show that a single dose of protecting virus can be given six weeks before, and 24 hours after an infection with flu virus and be effective. | Experiments so far show that a single dose of protecting virus can be given six weeks before, and 24 hours after an infection with flu virus and be effective. |
| The Warwick research team has now filed a patent on the protecting virus and is exploring ways of taking it through human clinical trials and testing on birds. | The Warwick research team has now filed a patent on the protecting virus and is exploring ways of taking it through human clinical trials and testing on birds. |
| Professor John Oxford, a virologist at Queen Mary College School of Medicine, London, said: "This is cutting edge science, but there is a lot that could still go wrong. | Professor John Oxford, a virologist at Queen Mary College School of Medicine, London, said: "This is cutting edge science, but there is a lot that could still go wrong. |
| "To have something that could more or less guarantee coverage against anything that this virus could throw at us would be absolutely spot on." | "To have something that could more or less guarantee coverage against anything that this virus could throw at us would be absolutely spot on." |