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Study uncovers new diabetes genes | Study uncovers new diabetes genes |
(1 day later) | |
Scientists have been able to identify three new genes which they say will bring them closer to understanding the causes of diabetes. | Scientists have been able to identify three new genes which they say will bring them closer to understanding the causes of diabetes. |
The discovery follows patient data gathered in Tayside and Fife by researchers from Dundee University. | The discovery follows patient data gathered in Tayside and Fife by researchers from Dundee University. |
Scientists from Oxford and Exeter have been working on the study. | Scientists from Oxford and Exeter have been working on the study. |
The three new genes that predispose people to develop Type 2 diabetes brings the total number of genes involved to nine. | The three new genes that predispose people to develop Type 2 diabetes brings the total number of genes involved to nine. |
The study was led jointly by researchers at the University of Oxford and the Peninsula Medical School in Exeter and forms part of the Wellcome Trust Case Control Consortium. | |
The information we have gathered here in Dundee is among the most detailed held anywhere in the world and is playing a key role in developments like this Professor Andrew Morris, University of Dundee | The information we have gathered here in Dundee is among the most detailed held anywhere in the world and is playing a key role in developments like this Professor Andrew Morris, University of Dundee |
The findings were published online on Thursday in the journal, Science. | |
About 200 million people worldwide have Type 2 diabetes, which results in the body failing to produce enough insulin to maintain normal blood sugar levels. | About 200 million people worldwide have Type 2 diabetes, which results in the body failing to produce enough insulin to maintain normal blood sugar levels. |
For each of the three new genes that have been discovered, researchers found there are two common "versions", one of which is associated with an increased risk of developing Type 2 diabetes and the other with reduced risk. | For each of the three new genes that have been discovered, researchers found there are two common "versions", one of which is associated with an increased risk of developing Type 2 diabetes and the other with reduced risk. |
Each high risk version increases the risk of Type 2 diabetes by between 10% and 20%. All the genes are common in the general population. | Each high risk version increases the risk of Type 2 diabetes by between 10% and 20%. All the genes are common in the general population. |
Professor Andrew Hattersley, of the Peninsula Medical School, said: "We now have significantly more pieces to the jigsaw that will help us understand the mechanisms behind Type 2 diabetes. | Professor Andrew Hattersley, of the Peninsula Medical School, said: "We now have significantly more pieces to the jigsaw that will help us understand the mechanisms behind Type 2 diabetes. |
'Real progress' | 'Real progress' |
"Each piece of new knowledge takes us a step closer towards a future with improved prevention and treatment of this very significant condition." | "Each piece of new knowledge takes us a step closer towards a future with improved prevention and treatment of this very significant condition." |
The initial findings of the study were confirmed by studying a further 9,000 samples from the UK, the majority of them from the Dundee area collected by researchers from the University of Dundee Medical School. | The initial findings of the study were confirmed by studying a further 9,000 samples from the UK, the majority of them from the Dundee area collected by researchers from the University of Dundee Medical School. |
Professor Andrew Morris, chair of Diabetic Medicine at the university, said: "The information we have gathered here in Dundee from the local population in Tayside and Fife is among the most detailed held anywhere in the world and is playing a key role in developments like this." | Professor Andrew Morris, chair of Diabetic Medicine at the university, said: "The information we have gathered here in Dundee from the local population in Tayside and Fife is among the most detailed held anywhere in the world and is playing a key role in developments like this." |
Diabetes UK welcomed the findings and said it was "real progress" towards preventing and treating Type 2 diabetes. | Diabetes UK welcomed the findings and said it was "real progress" towards preventing and treating Type 2 diabetes. |
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