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| Version 1 | Version 2 |
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| Swine flu 'shows drug resistance' | Swine flu 'shows drug resistance' |
| (10 minutes later) | |
| Experts have reported the first case of swine flu that is resistant to tamiflu - the main drug being used to fight the pandemic. | Experts have reported the first case of swine flu that is resistant to tamiflu - the main drug being used to fight the pandemic. |
| Roche Holding AG confirmed a patient with H1N1 influenza in Denmark showed resistance to the antiviral drug. | Roche Holding AG confirmed a patient with H1N1 influenza in Denmark showed resistance to the antiviral drug. |
| David Reddy, company executive, said it was not unexpected given that common seasonal flu could do the same. | David Reddy, company executive, said it was not unexpected given that common seasonal flu could do the same. |
| The news comes as a nine-year-old girl has become the third to die in the UK with swine flu. | The news comes as a nine-year-old girl has become the third to die in the UK with swine flu. |
| It is understood from her doctors at Birmingham Children's Hospital that she had underlying health conditions. It is not yet known whether swine flu contributed to her death. | It is understood from her doctors at Birmingham Children's Hospital that she had underlying health conditions. It is not yet known whether swine flu contributed to her death. |
| Meanwhile, the Department of Health has announced a big jump in the number of patients in England confirmed with swine flu - up 1,604 since Friday, taking the UK total so far to 5,937. | Meanwhile, the Department of Health has announced a big jump in the number of patients in England confirmed with swine flu - up 1,604 since Friday, taking the UK total so far to 5,937. |
| Routine sampling in the UK has shown that there is currently no resistance to oseltamivir or zanamivir A Health Protection Agency spokeswoman | |
| Experts have been using tamiflu, also known as oseltamivir, in a bid to stop the H1N1 spreading in communities. | Experts have been using tamiflu, also known as oseltamivir, in a bid to stop the H1N1 spreading in communities. |
| If taken early, it ensures that symptoms are mild and reduces the chance of a victim giving the illness to someone else. | If taken early, it ensures that symptoms are mild and reduces the chance of a victim giving the illness to someone else. |
| This first reported case of resistance developed in a swine flu patient taking Tamiflu. | This first reported case of resistance developed in a swine flu patient taking Tamiflu. |
| Mr Reddy stressed that there were no signs of a tamiflu-resistant strain of H1N1 circulating in the community. | Mr Reddy stressed that there were no signs of a tamiflu-resistant strain of H1N1 circulating in the community. |
| This is in contrast to seasonal H1N1 flu where a Tamiflu resistant strain emerged last year and is now widely circulating. | This is in contrast to seasonal H1N1 flu where a Tamiflu resistant strain emerged last year and is now widely circulating. |
| Experts fear if this were to happen, it could render tamiflu ineffective. | Experts fear if this were to happen, it could render tamiflu ineffective. |
| Another antiviral drug, called zanamivir or Relenza, made by GlaxoSmithKline, is also effective against swine flu. | Another antiviral drug, called zanamivir or Relenza, made by GlaxoSmithKline, is also effective against swine flu. |
| The UK government has been stockpiling these antiviral drugs and currently has enough to treat half of the population, with a contract to bring that up to 80% as soon as possible. | The UK government has been stockpiling these antiviral drugs and currently has enough to treat half of the population, with a contract to bring that up to 80% as soon as possible. |
| Supplies of flu vaccine have also been ordered and the first doses could be administered in the autumn. | Supplies of flu vaccine have also been ordered and the first doses could be administered in the autumn. |
| A spokeswoman for the Health Protection Agency said: "The Health Protection Agency continues to watch for antiviral resistance and will be carrying out regular sample testing throughout this outbreak. | A spokeswoman for the Health Protection Agency said: "The Health Protection Agency continues to watch for antiviral resistance and will be carrying out regular sample testing throughout this outbreak. |
| "We have been monitoring antiviral drug resistance since the beginning of this outbreak. Routine sampling in the UK has shown that there is currently no resistance to oseltamivir or zanamivir." | "We have been monitoring antiviral drug resistance since the beginning of this outbreak. Routine sampling in the UK has shown that there is currently no resistance to oseltamivir or zanamivir." |