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| One and done? Study suggests recovered Covid-19 patients may only need single vaccine dose | One and done? Study suggests recovered Covid-19 patients may only need single vaccine dose |
| (about 1 month later) | |
| Recovered Covid-19 patients showed significant antibody responses after just a single mRNA vaccine dose but apparently received little additional benefit following their second dose, promising new research has found. | Recovered Covid-19 patients showed significant antibody responses after just a single mRNA vaccine dose but apparently received little additional benefit following their second dose, promising new research has found. |
| Researchers led by E. John Wherry, PhD at the Penn Institute of Immunology took blood samples from 44 healthy individuals who received either the BioNTech/Pfizer or Moderna mRNA Covid-19 vaccine, both of which employ mRNA technology, 11 of whom had a prior Covid-19 infections. | Researchers led by E. John Wherry, PhD at the Penn Institute of Immunology took blood samples from 44 healthy individuals who received either the BioNTech/Pfizer or Moderna mRNA Covid-19 vaccine, both of which employ mRNA technology, 11 of whom had a prior Covid-19 infections. |
| Blood samples were taken at four stages both before and after receipt of the vaccines and the researchers noted something peculiar in the results; the Covid-free vaccine recipients, called Covid naïve, did not boast a full immune response until after their second dose but curiously, those previously-infected showed nearly full immune response after just one dose. | Blood samples were taken at four stages both before and after receipt of the vaccines and the researchers noted something peculiar in the results; the Covid-free vaccine recipients, called Covid naïve, did not boast a full immune response until after their second dose but curiously, those previously-infected showed nearly full immune response after just one dose. |
| “These results are encouraging for both short- and long-term vaccine efficacy, and this adds to our understanding of the mRNA vaccine immune response through the analysis of memory B cells,” said senior author Wherry. | “These results are encouraging for both short- and long-term vaccine efficacy, and this adds to our understanding of the mRNA vaccine immune response through the analysis of memory B cells,” said senior author Wherry. |
| Response to vaccines in humans is twofold: rapid response in the form of antibodies, and longer-term immunity, courtesy of memory B cells, which profile intruders so the immune system knows to fight them off if they ever show up again in the future. | Response to vaccines in humans is twofold: rapid response in the form of antibodies, and longer-term immunity, courtesy of memory B cells, which profile intruders so the immune system knows to fight them off if they ever show up again in the future. |
| This latest study highlights differences in memory B cell responses in recovered Covid-19 patients as compared to the Covid naive. | This latest study highlights differences in memory B cell responses in recovered Covid-19 patients as compared to the Covid naive. |
| “Memory B cells are a strong predictor of future antibody responses,” Wherry explained, adding that proper monitoring of memory B cell responses will play an important role in longer-term pandemic response and management, especially in the face of new mutations and variants. | “Memory B cells are a strong predictor of future antibody responses,” Wherry explained, adding that proper monitoring of memory B cell responses will play an important role in longer-term pandemic response and management, especially in the face of new mutations and variants. |
| The results suggest that only a single dose of the mRNA vaccines may be required to give recovered patients the necessary protection by triggering a maximal immune response from both antibodies and memory B cells, potentially freeing up supplies at some point in the future, amid a worldwide crunch. | The results suggest that only a single dose of the mRNA vaccines may be required to give recovered patients the necessary protection by triggering a maximal immune response from both antibodies and memory B cells, potentially freeing up supplies at some point in the future, amid a worldwide crunch. |
| The researchers noted that two doses were required to achieve full immune response among the covid-naive patients and this held true in analysis of antibodies against different variants of the coronavirus. | The researchers noted that two doses were required to achieve full immune response among the covid-naive patients and this held true in analysis of antibodies against different variants of the coronavirus. |
| “Everyone has good responses to the vaccines. They work to protect people against Covid-19. But for those who may be worried about side effects, they are not necessarily a bad thing–they may actually be an indicator of an even better immune response,” Wherry said. | “Everyone has good responses to the vaccines. They work to protect people against Covid-19. But for those who may be worried about side effects, they are not necessarily a bad thing–they may actually be an indicator of an even better immune response,” Wherry said. |
| Larger-scale studies are continuing with a view to determining the best course of action in terms of dosage numbers, overall immune response and lasting efficacy over time. | Larger-scale studies are continuing with a view to determining the best course of action in terms of dosage numbers, overall immune response and lasting efficacy over time. |
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