This article is from the source 'nytimes' and was first published or seen on . It last changed over 40 days ago and won't be checked again for changes.

You can find the current article at its original source at https://www.nytimes.com/2020/05/04/business/coronavirus-china-vaccine.html

The article has changed 18 times. There is an RSS feed of changes available.

Version 16 Version 17
China’s Coronavirus Vaccine Drive Empowers a Troubled Industry China’s Coronavirus Vaccine Drive Empowers a Troubled Industry
(7 days later)
China wants to beat the world in the race to find a coronavirus vaccine — and, by some measures, it is doing just that.China wants to beat the world in the race to find a coronavirus vaccine — and, by some measures, it is doing just that.
Desperate to protect its people and to deflect growing international criticism of how it handled the outbreak, it has slashed red tape and offered resources to drug companies. Four Chinese companies have started testing their vaccine candidates on humans, more than the United States and Britain combined.Desperate to protect its people and to deflect growing international criticism of how it handled the outbreak, it has slashed red tape and offered resources to drug companies. Four Chinese companies have started testing their vaccine candidates on humans, more than the United States and Britain combined.
But China’s leaders have empowered a vaccine industry that has long been mired in quality problems and scandals. Just two years ago, Chinese parents erupted in fury after they discovered ineffective vaccines had been given mostly to babies.But China’s leaders have empowered a vaccine industry that has long been mired in quality problems and scandals. Just two years ago, Chinese parents erupted in fury after they discovered ineffective vaccines had been given mostly to babies.
Finding a vaccine isn’t enough. China’s companies must also win over the trust of the public, who might be more inclined to choose a foreign-made vaccine over a Chinese one.Finding a vaccine isn’t enough. China’s companies must also win over the trust of the public, who might be more inclined to choose a foreign-made vaccine over a Chinese one.
“The Chinese now do not have confidence in the vaccines produced in China,” said Ray Yip, the former head of the Gates Foundation in China. “That’s probably going to be the biggest headache. If they didn’t have all those incidents, people will probably line up by the miles to get it.”“The Chinese now do not have confidence in the vaccines produced in China,” said Ray Yip, the former head of the Gates Foundation in China. “That’s probably going to be the biggest headache. If they didn’t have all those incidents, people will probably line up by the miles to get it.”
The need is urgent. More than 247,000 people have died globally, by official figures as of Monday, and the true count is probably much higher. The coronavirus remains stubbornly difficult to stamp out — even China, which officially appears to have tamed the spread, has suffered from sporadic outbreaks.The need is urgent. More than 247,000 people have died globally, by official figures as of Monday, and the true count is probably much higher. The coronavirus remains stubbornly difficult to stamp out — even China, which officially appears to have tamed the spread, has suffered from sporadic outbreaks.
China also wants to deflect accusations that its silencing of early warnings contributed to the global pandemic. Developing a vaccine for the world would, in addition, burnish its standing as a global scientific and medical power.China also wants to deflect accusations that its silencing of early warnings contributed to the global pandemic. Developing a vaccine for the world would, in addition, burnish its standing as a global scientific and medical power.
So China has made its vaccine a national priority, though it hasn’t disclosed spending details. One senior official said a vaccine for emergency use could be ready by September. State media has made a celebrity out of Chen Wei, the Chinese military’s top virologist, who is leading one of the vaccine efforts. The public is responding.So China has made its vaccine a national priority, though it hasn’t disclosed spending details. One senior official said a vaccine for emergency use could be ready by September. State media has made a celebrity out of Chen Wei, the Chinese military’s top virologist, who is leading one of the vaccine efforts. The public is responding.
Huang Shiyue, an 18-year-old first-year medical student in Wuhan, left her apartment on a recent early Sunday morning for the first time in three months to take a taxi to a wellness center an hour away. There, she offered up her arm in the name of science.Huang Shiyue, an 18-year-old first-year medical student in Wuhan, left her apartment on a recent early Sunday morning for the first time in three months to take a taxi to a wellness center an hour away. There, she offered up her arm in the name of science.
But in an illustration of how difficult it will be to find a safe and effective treatment, Ms. Huang grew dizzy and sick.But in an illustration of how difficult it will be to find a safe and effective treatment, Ms. Huang grew dizzy and sick.
“If I can help and benefit people with one little move,” she said, “then I think this is a very worthwhile thing.”“If I can help and benefit people with one little move,” she said, “then I think this is a very worthwhile thing.”
China’s vaccine drive has put Beijing’s considerable strengths and glaring weaknesses on display. With its firm hand on the levers of Chinese industry, Beijing can corral companies and scientists to reach national goals.China’s vaccine drive has put Beijing’s considerable strengths and glaring weaknesses on display. With its firm hand on the levers of Chinese industry, Beijing can corral companies and scientists to reach national goals.
At the same time, China’s vaccine companies have been accustomed to a closed political system that has a history of covering up safety scandals and protects them from foreign competition. Few invest heavily in research and development, and they have not discovered many products with global impact.At the same time, China’s vaccine companies have been accustomed to a closed political system that has a history of covering up safety scandals and protects them from foreign competition. Few invest heavily in research and development, and they have not discovered many products with global impact.
Instead, many invest more in selling and distribution, a large chunk of which includes managing relationships with local disease control centers. Experts say that creates incentives for corruption.Instead, many invest more in selling and distribution, a large chunk of which includes managing relationships with local disease control centers. Experts say that creates incentives for corruption.
China’s regulators also tend to look the other way when it comes to state-owned firms, which make up about 40 percent of the vaccine industry. Many vaccine makers operate with an expectation of impunity, knowing that even if they are found to have produced faulty products, they are unlikely to be shut down.China’s regulators also tend to look the other way when it comes to state-owned firms, which make up about 40 percent of the vaccine industry. Many vaccine makers operate with an expectation of impunity, knowing that even if they are found to have produced faulty products, they are unlikely to be shut down.
The vaccine that Ms. Huang received is being developed by CanSino Biologics, a Tianjin-based pharmaceutical firm, and the medical science arm of the People’s Liberation Army. The CanSino vaccine was the first to enter Phase 2 trials, which in the hierarchy of drug testing means it is further along than the world’s other candidates, though there is no guarantee that it will be proven effective. (It has been tested so far on 508 people; a candidate from Oxford University in Phase 1 trials, or earlier-stage testing, has been administered to twice as many people.)The vaccine that Ms. Huang received is being developed by CanSino Biologics, a Tianjin-based pharmaceutical firm, and the medical science arm of the People’s Liberation Army. The CanSino vaccine was the first to enter Phase 2 trials, which in the hierarchy of drug testing means it is further along than the world’s other candidates, though there is no guarantee that it will be proven effective. (It has been tested so far on 508 people; a candidate from Oxford University in Phase 1 trials, or earlier-stage testing, has been administered to twice as many people.)
One other Chinese institution also has a candidate in Phase 2 testing — the Wuhan Institute of Biological Products, an arm of state-run Sinopharm Group. Sinovac Biotech, a private company and the Beijing Institute of Biological Products, which also belongs to Sinopharm, have potential vaccines in Phase 1 trials.One other Chinese institution also has a candidate in Phase 2 testing — the Wuhan Institute of Biological Products, an arm of state-run Sinopharm Group. Sinovac Biotech, a private company and the Beijing Institute of Biological Products, which also belongs to Sinopharm, have potential vaccines in Phase 1 trials.
The Wuhan institute was involved in a 2018 scandal in which defective vaccines for diphtheria, tetanus, whooping cough and other conditions were injected into hundreds of thousands of babies. China imposed a $1.3 billion fine on another virus maker involved, Changchun Changsheng. The scandal led to the firing of dozens of officials and pledges of a swift industry cleanup.The Wuhan institute was involved in a 2018 scandal in which defective vaccines for diphtheria, tetanus, whooping cough and other conditions were injected into hundreds of thousands of babies. China imposed a $1.3 billion fine on another virus maker involved, Changchun Changsheng. The scandal led to the firing of dozens of officials and pledges of a swift industry cleanup.
The government confiscated the Wuhan institute’s “illegal income,” fined the company and punished nine executives.The government confiscated the Wuhan institute’s “illegal income,” fined the company and punished nine executives.
The Wuhan institute has been sued at least twice in China by plaintiffs who have alleged that the institute’s vaccines have caused “abnormal reactions,” according to court documents. In both cases, the court ruled that the Wuhan institute had to partially compensate the victims a total of roughly $71,500. Its executives have been accused at least three times of bribing officials at local centers for disease and control in various provinces to thank them for purchasing their vaccines. The executives were convicted but no criminal charges were pursued against the company.The Wuhan institute has been sued at least twice in China by plaintiffs who have alleged that the institute’s vaccines have caused “abnormal reactions,” according to court documents. In both cases, the court ruled that the Wuhan institute had to partially compensate the victims a total of roughly $71,500. Its executives have been accused at least three times of bribing officials at local centers for disease and control in various provinces to thank them for purchasing their vaccines. The executives were convicted but no criminal charges were pursued against the company.
Sinovac Biotech had also been involved in a bribery scandal, according to court documents. From 2002 to 2014, a court in Beijing said, the general manager of Sinovac Biotech gave China’s deputy director in charge of drug evaluations nearly $50,000 to help the firm with drug approvals. Sinovac was not charged. The general manager was a man surnamed Yin, the documents showed. Chinese media reports have said that person is the current chief executive, Yin Weidong, who held the title of general manager from 2001 to 2017.Sinovac Biotech had also been involved in a bribery scandal, according to court documents. From 2002 to 2014, a court in Beijing said, the general manager of Sinovac Biotech gave China’s deputy director in charge of drug evaluations nearly $50,000 to help the firm with drug approvals. Sinovac was not charged. The general manager was a man surnamed Yin, the documents showed. Chinese media reports have said that person is the current chief executive, Yin Weidong, who held the title of general manager from 2001 to 2017.
Sinovac, the Wuhan institute, and its parent, China National Biotec Group, did not respond to requests for comment.Sinovac, the Wuhan institute, and its parent, China National Biotec Group, did not respond to requests for comment.
Updated July 7, 2020
The coronavirus can stay aloft for hours in tiny droplets in stagnant air, infecting people as they inhale, mounting scientific evidence suggests. This risk is highest in crowded indoor spaces with poor ventilation, and may help explain super-spreading events reported in meatpacking plants, churches and restaurants. It’s unclear how often the virus is spread via these tiny droplets, or aerosols, compared with larger droplets that are expelled when a sick person coughs or sneezes, or transmitted through contact with contaminated surfaces, said Linsey Marr, an aerosol expert at Virginia Tech. Aerosols are released even when a person without symptoms exhales, talks or sings, according to Dr. Marr and more than 200 other experts, who have outlined the evidence in an open letter to the World Health Organization.
Common symptoms include fever, a dry cough, fatigue and difficulty breathing or shortness of breath. Some of these symptoms overlap with those of the flu, making detection difficult, but runny noses and stuffy sinuses are less common. The C.D.C. has also added chills, muscle pain, sore throat, headache and a new loss of the sense of taste or smell as symptoms to look out for. Most people fall ill five to seven days after exposure, but symptoms may appear in as few as two days or as many as 14 days.
Scientists around the country have tried to identify everyday materials that do a good job of filtering microscopic particles. In recent tests, HEPA furnace filters scored high, as did vacuum cleaner bags, fabric similar to flannel pajamas and those of 600-count pillowcases. Other materials tested included layered coffee filters and scarves and bandannas. These scored lower, but still captured a small percentage of particles.
A commentary published this month on the website of the British Journal of Sports Medicine points out that covering your face during exercise “comes with issues of potential breathing restriction and discomfort” and requires “balancing benefits versus possible adverse events.” Masks do alter exercise, says Cedric X. Bryant, the president and chief science officer of the American Council on Exercise, a nonprofit organization that funds exercise research and certifies fitness professionals. “In my personal experience,” he says, “heart rates are higher at the same relative intensity when you wear a mask.” Some people also could experience lightheadedness during familiar workouts while masked, says Len Kravitz, a professor of exercise science at the University of New Mexico.
The steroid, dexamethasone, is the first treatment shown to reduce mortality in severely ill patients, according to scientists in Britain. The drug appears to reduce inflammation caused by the immune system, protecting the tissues. In the study, dexamethasone reduced deaths of patients on ventilators by one-third, and deaths of patients on oxygen by one-fifth.
The coronavirus emergency relief package gives many American workers paid leave if they need to take time off because of the virus. It gives qualified workers two weeks of paid sick leave if they are ill, quarantined or seeking diagnosis or preventive care for coronavirus, or if they are caring for sick family members. It gives 12 weeks of paid leave to people caring for children whose schools are closed or whose child care provider is unavailable because of the coronavirus. It is the first time the United States has had widespread federally mandated paid leave, and includes people who don’t typically get such benefits, like part-time and gig economy workers. But the measure excludes at least half of private-sector workers, including those at the country’s largest employers, and gives small employers significant leeway to deny leave.
So far, the evidence seems to show it does. A widely cited paper published in April suggests that people are most infectious about two days before the onset of coronavirus symptoms and estimated that 44 percent of new infections were a result of transmission from people who were not yet showing symptoms. Recently, a top expert at the World Health Organization stated that transmission of the coronavirus by people who did not have symptoms was “very rare,” but she later walked back that statement.
Touching contaminated objects and then infecting ourselves with the germs is not typically how the virus spreads. But it can happen. A number of studies of flu, rhinovirus, coronavirus and other microbes have shown that respiratory illnesses, including the new coronavirus, can spread by touching contaminated surfaces, particularly in places like day care centers, offices and hospitals. But a long chain of events has to happen for the disease to spread that way. The best way to protect yourself from coronavirus — whether it’s surface transmission or close human contact — is still social distancing, washing your hands, not touching your face and wearing masks.
A study by European scientists is the first to document a strong statistical link between genetic variations and Covid-19, the illness caused by the coronavirus. Having Type A blood was linked to a 50 percent increase in the likelihood that a patient would need to get oxygen or to go on a ventilator, according to the new study.
If air travel is unavoidable, there are some steps you can take to protect yourself. Most important: Wash your hands often, and stop touching your face. If possible, choose a window seat. A study from Emory University found that during flu season, the safest place to sit on a plane is by a window, as people sitting in window seats had less contact with potentially sick people. Disinfect hard surfaces. When you get to your seat and your hands are clean, use disinfecting wipes to clean the hard surfaces at your seat like the head and arm rest, the seatbelt buckle, the remote, screen, seat back pocket and the tray table. If the seat is hard and nonporous or leather or pleather, you can wipe that down, too. (Using wipes on upholstered seats could lead to a wet seat and spreading of germs rather than killing them.)
If you’ve been exposed to the coronavirus or think you have, and have a fever or symptoms like a cough or difficulty breathing, call a doctor. They should give you advice on whether you should be tested, how to get tested, and how to seek medical treatment without potentially infecting or exposing others.
Despite the companies’ earlier stumbles, the Chinese government has given them permission to accelerate trials. Regulators in the United States and other places have done the same for other companies. The Wuhan institute, Sinovac and the Beijing institute got combined approvals to run the first two phases, a decision questioned by several Chinese scientists, who felt that safety results from the first phase should be evaluated before the second phase was begun.Despite the companies’ earlier stumbles, the Chinese government has given them permission to accelerate trials. Regulators in the United States and other places have done the same for other companies. The Wuhan institute, Sinovac and the Beijing institute got combined approvals to run the first two phases, a decision questioned by several Chinese scientists, who felt that safety results from the first phase should be evaluated before the second phase was begun.
Ding Sheng, the dean of the pharmacy school at Tsinghua University in Beijing, said that some companies were “adopting unconventional methods” in the preclinical research stage, running tasks like the design process and animal modeling at the same time when they should be done consecutively, according to the People’s Daily, the Communist Party’s official newspaper.Ding Sheng, the dean of the pharmacy school at Tsinghua University in Beijing, said that some companies were “adopting unconventional methods” in the preclinical research stage, running tasks like the design process and animal modeling at the same time when they should be done consecutively, according to the People’s Daily, the Communist Party’s official newspaper.
“I understand the people’s eager anticipation of a vaccine,” Dr. Ding was quoted as saying. “But from a scientific point of view, no matter how anxious we are, we cannot lower our standards.” He did not respond to a request for comment.“I understand the people’s eager anticipation of a vaccine,” Dr. Ding was quoted as saying. “But from a scientific point of view, no matter how anxious we are, we cannot lower our standards.” He did not respond to a request for comment.
Dr. Chen’s academy issued calls on the internet for phase one volunteers. Ms. Huang successfully registered for the second round on April 10. The next day, she got a call and text message: Please come tomorrow.Dr. Chen’s academy issued calls on the internet for phase one volunteers. Ms. Huang successfully registered for the second round on April 10. The next day, she got a call and text message: Please come tomorrow.
“Of course, I was worried at the beginning,” she said. “To say you’re not at all worried is impossible, right?” She surfed the internet and called her teacher, who listed pros and cons. She sought advice from her parents.“Of course, I was worried at the beginning,” she said. “To say you’re not at all worried is impossible, right?” She surfed the internet and called her teacher, who listed pros and cons. She sought advice from her parents.
Then she went. Workers ran an antibody test, to make sure she was not already immune to the coronavirus, an H.I.V. test and a pregnancy test.Then she went. Workers ran an antibody test, to make sure she was not already immune to the coronavirus, an H.I.V. test and a pregnancy test.
The participants were divided into low- and medium-dose groups and another placebo group, as part of a “double-blind” experiment. They were not told their group.The participants were divided into low- and medium-dose groups and another placebo group, as part of a “double-blind” experiment. They were not told their group.
Fifteen minutes after Ms. Huang got her shot, she started to feel dizzy. Her stomach hurt. Her heart began beating fast. She got diarrhea.Fifteen minutes after Ms. Huang got her shot, she started to feel dizzy. Her stomach hurt. Her heart began beating fast. She got diarrhea.
Dr. Chen and other doctors checked her. Someone offered her hot water. She took a walk in the sun. Finally, they took her in an ambulance to a subway station, where she took a taxi home.Dr. Chen and other doctors checked her. Someone offered her hot water. She took a walk in the sun. Finally, they took her in an ambulance to a subway station, where she took a taxi home.
Ms. Huang said she feels fine at home.Ms. Huang said she feels fine at home.
Shi Zibo, a junior in college, also signed up to be a volunteer and got the shot on April 12. On the fourth day, he got a slight fever but said he has no other side effects.Shi Zibo, a junior in college, also signed up to be a volunteer and got the shot on April 12. On the fourth day, he got a slight fever but said he has no other side effects.
“I felt very proud when I received the call,” Mr. Shi said. “There are not many opportunities for me in to contribute to other people in this life, so I will not regret it, regardless of the final result.”“I felt very proud when I received the call,” Mr. Shi said. “There are not many opportunities for me in to contribute to other people in this life, so I will not regret it, regardless of the final result.”
Amber Wang and Liu Yi contributed research in Beijing.Amber Wang and Liu Yi contributed research in Beijing.