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Coronavirus Live Updates: With Over 300,000 Cases and 8,000 Deaths, the U.S. Braces for Still More Coronavirus Live Updates: With Over 300,000 Cases and 8,000 Deaths, the U.S. Braces for Still More
(32 minutes later)
新冠病毒疫情最新消息新冠病毒疫情最新消息
The United States on Saturday experienced its first full day under a federal recommendation that people wear cloth masks when they go out in public in many instances, the latest effort to contain the coronavirus pandemic that has seen more than 1 million people worldwide become infected.The United States on Saturday experienced its first full day under a federal recommendation that people wear cloth masks when they go out in public in many instances, the latest effort to contain the coronavirus pandemic that has seen more than 1 million people worldwide become infected.
With President Trump having undercut the new guidance of the Centers for Disease Control and Prevention by immediately declaring that he would not wear a mask himself, it was far from clear how many Americans would ultimately embrace the recommendation.With President Trump having undercut the new guidance of the Centers for Disease Control and Prevention by immediately declaring that he would not wear a mask himself, it was far from clear how many Americans would ultimately embrace the recommendation.
Some state and local officials have made a point of wearing facial coverings, and at least a couple of localities have even required them by ordinance. But health experts have also feared that people would don masks only to loosen their compliance with social distancing guidelines.Some state and local officials have made a point of wearing facial coverings, and at least a couple of localities have even required them by ordinance. But health experts have also feared that people would don masks only to loosen their compliance with social distancing guidelines.
More than 300,000 people in the United States have tested positive for the virus, and officials believe that the number of people who have been infected is far higher. More than 8,000 people have died, including at least 3,565 in New York, the hardest hit state.More than 300,000 people in the United States have tested positive for the virus, and officials believe that the number of people who have been infected is far higher. More than 8,000 people have died, including at least 3,565 in New York, the hardest hit state.
Globally, cases passed 1.1 million and deaths passed 59,000. The British government reported 708 deaths — a grim national record for a 24-hour period.Globally, cases passed 1.1 million and deaths passed 59,000. The British government reported 708 deaths — a grim national record for a 24-hour period.
The recommendation for masks in the United States followed an intense West Wing debate over several days as a divided Trump administration wrestled with whether to request such a drastic change in Americans’ social behavior.The recommendation for masks in the United States followed an intense West Wing debate over several days as a divided Trump administration wrestled with whether to request such a drastic change in Americans’ social behavior.
Ultimately, the C.D.C. suggested that people wear what it described as “simple cloth face coverings” when they are in places, like grocery stores and pharmacies, where it might be more challenging to keep away from others.Ultimately, the C.D.C. suggested that people wear what it described as “simple cloth face coverings” when they are in places, like grocery stores and pharmacies, where it might be more challenging to keep away from others.
“It is critical to emphasize that maintaining 6-feet social distancing remains important to slowing the spread of the virus,” the C.D.C. wrote in its recommendation, which it said was partly intended to “help people who may have the virus and do not know it from transmitting it to others.”“It is critical to emphasize that maintaining 6-feet social distancing remains important to slowing the spread of the virus,” the C.D.C. wrote in its recommendation, which it said was partly intended to “help people who may have the virus and do not know it from transmitting it to others.”
But Mr. Trump, in an appearance at the White House on Friday evening, repeatedly described the recommendation as voluntary and made clear that he did not intend to wear a mask.But Mr. Trump, in an appearance at the White House on Friday evening, repeatedly described the recommendation as voluntary and made clear that he did not intend to wear a mask.
Federal officials are scheduled to speak at the White House on Saturday afternoon. Federal officials were speaking at the White House on Saturday afternoon.
Gov. Andrew M. Cuomo warned Saturday that, as infections passed 113,700 and deaths 3,500, New York State would reach the worst point of the coronavirus crisis within a week or so.Gov. Andrew M. Cuomo warned Saturday that, as infections passed 113,700 and deaths 3,500, New York State would reach the worst point of the coronavirus crisis within a week or so.
“Nobody can tell you the number at the top of the mountain,” Mr. Cuomo said, but he estimated that it would be “in the seven-day range.”“Nobody can tell you the number at the top of the mountain,” Mr. Cuomo said, but he estimated that it would be “in the seven-day range.”
He also said that 85,000 people had volunteered to help New York fight the coronavirus and that 22,000 of them were from out of state, and that the Chinese government was facilitating a donation of 1,000 ventilators to New York and Oregon was sending 140 as the state rushes to increase its supply.He also said that 85,000 people had volunteered to help New York fight the coronavirus and that 22,000 of them were from out of state, and that the Chinese government was facilitating a donation of 1,000 ventilators to New York and Oregon was sending 140 as the state rushes to increase its supply.
Mr. Cuomo and Mayor Bill de Blasio of New York have cited shortages of hospital equipment, something President Trump seemed to allude to in attacking the news media at a White House Briefing on Saturday.Mr. Cuomo and Mayor Bill de Blasio of New York have cited shortages of hospital equipment, something President Trump seemed to allude to in attacking the news media at a White House Briefing on Saturday.
“I guess they’re looking for ratings,” Mr. Trump said of unnamed media outlets. “I don’t know what they’re looking for.” He suggested that accounts of supply shortages at hospitals had been exaggerated. Mr. Trump said many hospital administrators had reported that their supply levels “are meeting their essential needs,” adding that they are “really thrilled to be where they are.”“I guess they’re looking for ratings,” Mr. Trump said of unnamed media outlets. “I don’t know what they’re looking for.” He suggested that accounts of supply shortages at hospitals had been exaggerated. Mr. Trump said many hospital administrators had reported that their supply levels “are meeting their essential needs,” adding that they are “really thrilled to be where they are.”
Mr. Trump also criticized Mr. Cuomo on the issue of ventilators.Mr. Trump also criticized Mr. Cuomo on the issue of ventilators.
“He wanted 40,000 ventilators,” he said. “Now the governor, as you know, had a chance to get 16,000 a few years ago. He decided not to get that. The State of New York has asked for help. I’ve given them four hospitals, four medical centers, then I gave them an additional hospital, then I gave them military people to operate the hospital.”“He wanted 40,000 ventilators,” he said. “Now the governor, as you know, had a chance to get 16,000 a few years ago. He decided not to get that. The State of New York has asked for help. I’ve given them four hospitals, four medical centers, then I gave them an additional hospital, then I gave them military people to operate the hospital.”
“We have given the governor of New York more than anybody has ever been given in a long time, I’ll just say,” Mr. Trump added. “I was going to say in history, but in a long time. And I think he’s happy, but I think that, because I watched what he said today, and it was fine. I wouldn’t say gracious. It wasn’t gracious. It was OK.”“We have given the governor of New York more than anybody has ever been given in a long time, I’ll just say,” Mr. Trump added. “I was going to say in history, but in a long time. And I think he’s happy, but I think that, because I watched what he said today, and it was fine. I wouldn’t say gracious. It wasn’t gracious. It was OK.”
The president also announced at the briefing that 1,000 military personnel, most of them doctors and nurses, were being deployed to New York City to “assist where they’re needed the most. That’s the hottest of all the hot spots.”The president also announced at the briefing that 1,000 military personnel, most of them doctors and nurses, were being deployed to New York City to “assist where they’re needed the most. That’s the hottest of all the hot spots.”
Earlier in the day, Mr. de Blasio said the city was heading into “the toughest time,” and repeated his calls for a national enlistment system to help move doctors and health care workers around the country to areas with high need.Earlier in the day, Mr. de Blasio said the city was heading into “the toughest time,” and repeated his calls for a national enlistment system to help move doctors and health care workers around the country to areas with high need.
“This is going to be like having many Katrinas,” Mr. de Blasio said on MSNBC’s “AM Joy.” “This is going to be a reality where you are going to have many cities and states simultaneously in crisis, needing health care professionals, needing ventilators.”“This is going to be like having many Katrinas,” Mr. de Blasio said on MSNBC’s “AM Joy.” “This is going to be a reality where you are going to have many cities and states simultaneously in crisis, needing health care professionals, needing ventilators.”
The mayor has said that the city will need 45,000 more medical personnel to fight the pandemic through April and May.The mayor has said that the city will need 45,000 more medical personnel to fight the pandemic through April and May.
Dr. Sheldon H. Teperman, director of the trauma center at NYC Health + Hospitals/Jacobi in the Bronx, said that the disease had particularly thinned the ranks of specialized critical-care nurses at city-run hospitals, with some falling ill or needing to care for sick family members.Dr. Sheldon H. Teperman, director of the trauma center at NYC Health + Hospitals/Jacobi in the Bronx, said that the disease had particularly thinned the ranks of specialized critical-care nurses at city-run hospitals, with some falling ill or needing to care for sick family members.
“If we could get critical-care nurses, if volunteers would just come, we could save more lives,” Dr. Teperman said.“If we could get critical-care nurses, if volunteers would just come, we could save more lives,” Dr. Teperman said.
Mr. Cuomo tried to encourage New Yorkers not to lose hope even as he said he expected the numbers of those infected and dying to continue to surge in the nation’s largest and most lethal outbreak.Mr. Cuomo tried to encourage New Yorkers not to lose hope even as he said he expected the numbers of those infected and dying to continue to surge in the nation’s largest and most lethal outbreak.
“This is a painful, disorienting experience,” he said. “But we find our best self, our strongest self — this day will end. We will get through it, we will get to the other side of the mountain. But we have to do what we have to do between now and then.”“This is a painful, disorienting experience,” he said. “But we find our best self, our strongest self — this day will end. We will get through it, we will get to the other side of the mountain. But we have to do what we have to do between now and then.”
In New Jersey, Gov. Philip D. Murphy announced that there had been 200 more deaths in the state since Friday, bringing New Jersey’s total to 846 — which he noted was more than the number of New Jersey residents who died in the Sept. 11 terrorist attacks.In New Jersey, Gov. Philip D. Murphy announced that there had been 200 more deaths in the state since Friday, bringing New Jersey’s total to 846 — which he noted was more than the number of New Jersey residents who died in the Sept. 11 terrorist attacks.
Citing shore towns increasingly crowded by those fleeing other hot spots, Mr. Murphy announced that New Jersey would move to make it easier for municipalities or counties to block “rentals to transient guests or seasonal tenants” during the crisis, including at hotels and motels.Citing shore towns increasingly crowded by those fleeing other hot spots, Mr. Murphy announced that New Jersey would move to make it easier for municipalities or counties to block “rentals to transient guests or seasonal tenants” during the crisis, including at hotels and motels.
President Trump on Saturday lashed out at the Navy captain who was dismissed after he wrote a letter to his commanders and sought more help as the coronavirus spread through his ship.
“I thought it was terrible what he did,” Mr. Trump said of Capt. Brett E. Crozier, who commanded the aircraft carrier Theodore Roosevelt. “To write a letter? This isn’t a class on literature. This is a captain of a massive ship that’s nuclear powered, and he shouldn’t be talking that way in a letter. He could call and ask and suggest.”
In the letter, which was sent to dozens of people and eventually leaked to the news media, Captain Crozier depicted the Navy as having failed to provide the necessary resources to combat the virus aboard the Roosevelt, which has a crew of almost 5,000.
Videos posted on social media showed that Captain Crozier received a rousing ovation when he left the docked ship in Guam.
But some Navy officials complained that the letter had stirred panic, both on the ship and ashore, and said that his approach to airing his concerns prompted them to lose confidence in his ability to command the Roosevelt.
At the White House on Saturday, Mr. Trump said he supported the Pentagon’s decision to remove the captain.
“I agree with their decision 100 percent,” he said.
The Centers for Disease Control and Prevention has begun to conduct tests to find out whether people have been previously infected with the coronavirus, officials said Saturday.The Centers for Disease Control and Prevention has begun to conduct tests to find out whether people have been previously infected with the coronavirus, officials said Saturday.
Such testing can help determine how widespread the disease has been and whether there have been significant numbers of people who were infected but did not become ill. The tests, called serology tests, detect antibodies that the immune system makes in response to the virus.Such testing can help determine how widespread the disease has been and whether there have been significant numbers of people who were infected but did not become ill. The tests, called serology tests, detect antibodies that the immune system makes in response to the virus.
According to Dr. Joe Bresee, deputy incident manager of the agency’s Covid-19 response, testing will focus on three groups: people in areas with a high concentration of cases; people in a representative sample of other areas from around the country; and special groups of people who are likely to have had a higher risk of exposure, like health care workers.According to Dr. Joe Bresee, deputy incident manager of the agency’s Covid-19 response, testing will focus on three groups: people in areas with a high concentration of cases; people in a representative sample of other areas from around the country; and special groups of people who are likely to have had a higher risk of exposure, like health care workers.
Antibodies to other viruses confer immunity, but it is not yet certain that they do for the novel coronavirus. Still, Dr. Anthony S. Fauci, the top U.S. infectious disease expert, said last week that “if this virus acts like every other virus that we know, once you get infected, get better, clear the virus, then you’ll have immunity that will protect you against re-infection.”Antibodies to other viruses confer immunity, but it is not yet certain that they do for the novel coronavirus. Still, Dr. Anthony S. Fauci, the top U.S. infectious disease expert, said last week that “if this virus acts like every other virus that we know, once you get infected, get better, clear the virus, then you’ll have immunity that will protect you against re-infection.”
And while some countries, like Italy and Britain, have raised the possibility of giving people with antibodies permits to allow them to return to the work force, officials with the C.D.C. said their testing was to determine the virus’s trail and to plan ahead.And while some countries, like Italy and Britain, have raised the possibility of giving people with antibodies permits to allow them to return to the work force, officials with the C.D.C. said their testing was to determine the virus’s trail and to plan ahead.
The C.D.C. also said on Saturday that it had expanded the coronavirus information it publishes online, adding a weekly report that will include figures on outpatient and emergency department visits, hospitalizations, deaths and data on testing for the virus.The C.D.C. also said on Saturday that it had expanded the coronavirus information it publishes online, adding a weekly report that will include figures on outpatient and emergency department visits, hospitalizations, deaths and data on testing for the virus.
The first report confirms an aspect of the epidemic that has already been noted: People 65 and over are most likely to become severely ill if infected. Those 50 and older also have a somewhat higher than average risk of serious illness.The first report confirms an aspect of the epidemic that has already been noted: People 65 and over are most likely to become severely ill if infected. Those 50 and older also have a somewhat higher than average risk of serious illness.
At least 430,000 people have arrived in the United States on direct flights from China since that country disclosed the existence of a pneumonialike illness to international health experts on New Year’s Eve, according to an analysis of data collected in both countries.At least 430,000 people have arrived in the United States on direct flights from China since that country disclosed the existence of a pneumonialike illness to international health experts on New Year’s Eve, according to an analysis of data collected in both countries.
Nearly 40,000 of them have come in the two months since President Trump imposed travel restrictions.Nearly 40,000 of them have come in the two months since President Trump imposed travel restrictions.
In total, 279 passenger flights have arrived from China since the restrictions, carrying Americans and others exempt from them. Even this past week, data show, the flights have continued.In total, 279 passenger flights have arrived from China since the restrictions, carrying Americans and others exempt from them. Even this past week, data show, the flights have continued.
Mr. Trump has heralded the restrictions as one of his administration’s most important decisions in light of the outbreak. And the bulk of the 430,000 passengers — of varying nationalities — arrived in January, before they were imposed. But the analysis of the flight and other data by The New York Times shows the travel measures, however effective, may have come too late, particularly in light of recent statements from officials that as many as 25 percent of infected people may never have symptoms.Mr. Trump has heralded the restrictions as one of his administration’s most important decisions in light of the outbreak. And the bulk of the 430,000 passengers — of varying nationalities — arrived in January, before they were imposed. But the analysis of the flight and other data by The New York Times shows the travel measures, however effective, may have come too late, particularly in light of recent statements from officials that as many as 25 percent of infected people may never have symptoms.
And even with the restrictions, screening procedures have been uneven, interviews show.And even with the restrictions, screening procedures have been uneven, interviews show.
“I was surprised at how lax the whole process was,” said Andrew Wu, 31, who landed at Los Angeles International Airport from Beijing on March 10. “The guy I spoke to read down a list of questions, and he didn’t seem interested in checking out anything.”“I was surprised at how lax the whole process was,” said Andrew Wu, 31, who landed at Los Angeles International Airport from Beijing on March 10. “The guy I spoke to read down a list of questions, and he didn’t seem interested in checking out anything.”
At least 17 Egyptian doctors and nurses have tested positive for the coronavirus, the National Cancer Institute in Cairo said on Saturday, raising fears the pandemic could have a devastating effect on health facilities in the Arab world’s most populous country.At least 17 Egyptian doctors and nurses have tested positive for the coronavirus, the National Cancer Institute in Cairo said on Saturday, raising fears the pandemic could have a devastating effect on health facilities in the Arab world’s most populous country.
The outbreak was the first reported among medical workers in Egypt, which recorded an increase in the rate of infections over the weekend: The health ministry recorded 120 cases on Friday, raising the total to 985, with 66 deaths.The outbreak was the first reported among medical workers in Egypt, which recorded an increase in the rate of infections over the weekend: The health ministry recorded 120 cases on Friday, raising the total to 985, with 66 deaths.
Cairo University, which runs the cancer hospital, said in a statement that all medical workers at the facility were being tested, and that the hospital would be closed and sanitized.Cairo University, which runs the cancer hospital, said in a statement that all medical workers at the facility were being tested, and that the hospital would be closed and sanitized.
The Egyptian medical syndicate, an association representing hundreds of thousands of medical workers, said in a statement that it was “shocked” by the number of cases and urged the authorities to supply protection equipment and apply strict testing protocols.The Egyptian medical syndicate, an association representing hundreds of thousands of medical workers, said in a statement that it was “shocked” by the number of cases and urged the authorities to supply protection equipment and apply strict testing protocols.
It said in a post on Facebook that the infected medical workers had been placed in quarantine.It said in a post on Facebook that the infected medical workers had been placed in quarantine.
The coronavirus pandemic has sickened more than 1.1 million people, according to official counts. As of Saturday morning, at least 59,000 people have died, and the virus has been detected in at least 175 countries. Here’s the view from around the globe.The coronavirus pandemic has sickened more than 1.1 million people, according to official counts. As of Saturday morning, at least 59,000 people have died, and the virus has been detected in at least 175 countries. Here’s the view from around the globe.
Spain: The country reported 7,026 new cases, for a total of 124,736, surpassing Italy as the nation with the most infections in Europe. Spain said that 809 coronavirus patients, including a 5-year-old, had died overnight. It was the lowest toll in a week, bringing total deaths to 11,744. Also on Saturday, Prime Minister Pedro Sánchez said that the nationwide lockdown would be extended another 15 days.Spain: The country reported 7,026 new cases, for a total of 124,736, surpassing Italy as the nation with the most infections in Europe. Spain said that 809 coronavirus patients, including a 5-year-old, had died overnight. It was the lowest toll in a week, bringing total deaths to 11,744. Also on Saturday, Prime Minister Pedro Sánchez said that the nationwide lockdown would be extended another 15 days.
France: Officials reported 68,605 test-confirmed cases of Covid-19 around the country and 7,560 deaths, as well as 6,838 patients in intensive care. In an encouraging sign, the country has recorded fewer and fewer new patients in intensive care each day over the past week — on Saturday there were 176 new patients, versus 486 a week ago.France: Officials reported 68,605 test-confirmed cases of Covid-19 around the country and 7,560 deaths, as well as 6,838 patients in intensive care. In an encouraging sign, the country has recorded fewer and fewer new patients in intensive care each day over the past week — on Saturday there were 176 new patients, versus 486 a week ago.
Britain: Thousands of prisoners in Britain will be granted early release within weeks in an effort to contain the spread of the virus in cells and facilities where social distancing rules are impossible to maintain, the Ministry of Justice said. The announcement comes as the country reported a record 708 deaths overnight, bringing the total to more than 4,300.Britain: Thousands of prisoners in Britain will be granted early release within weeks in an effort to contain the spread of the virus in cells and facilities where social distancing rules are impossible to maintain, the Ministry of Justice said. The announcement comes as the country reported a record 708 deaths overnight, bringing the total to more than 4,300.
Ecuador: The health minister said there was a “sharp rise” in coronavirus deaths on Friday in Guayaquil, the center of the country’s outbreak, with the toll rising to 1,500 from 700. The government has said it is building a “special camp” for coronavirus patients in Guayaquil, where residents are under strict quarantine and curfew measures, leaving police officers and soldiers to collect the bodies of the dead from homes — as many as 150 a day — and have been tasked with burying the dead.Ecuador: The health minister said there was a “sharp rise” in coronavirus deaths on Friday in Guayaquil, the center of the country’s outbreak, with the toll rising to 1,500 from 700. The government has said it is building a “special camp” for coronavirus patients in Guayaquil, where residents are under strict quarantine and curfew measures, leaving police officers and soldiers to collect the bodies of the dead from homes — as many as 150 a day — and have been tasked with burying the dead.
Republic of Georgia: A 79-year-old woman in the South Caucasus region became the country’s first reported death related to the pandemic. Medical officials said she had other underlying conditions. Georgia, a nation of 3.7 million people, reported a total of 157 confirmed cases.Republic of Georgia: A 79-year-old woman in the South Caucasus region became the country’s first reported death related to the pandemic. Medical officials said she had other underlying conditions. Georgia, a nation of 3.7 million people, reported a total of 157 confirmed cases.
Germany: The country has identified 91,000 coronavirus infections, more reported cases than all but the United States, Spain and Italy. But thanks to widespread testing and other measures, its percentage of fatal cases has been remarkably low — 1.3 percent. By contrast, the reported rate is about 10 percent in Spain, France and Britain, 4 percent in China and 2.5 percent in the United States. Even South Korea, a model of flattening the curve, has a rate of 1.7 percent.Germany: The country has identified 91,000 coronavirus infections, more reported cases than all but the United States, Spain and Italy. But thanks to widespread testing and other measures, its percentage of fatal cases has been remarkably low — 1.3 percent. By contrast, the reported rate is about 10 percent in Spain, France and Britain, 4 percent in China and 2.5 percent in the United States. Even South Korea, a model of flattening the curve, has a rate of 1.7 percent.
The weeks of locking down Italy, which has had the world’s deadliest coronavirus outbreak, may be starting to pay off, as officials announced this week that the numbers of new infections had plateaued and, on Saturday, that ICU cases had gone for the first time.The weeks of locking down Italy, which has had the world’s deadliest coronavirus outbreak, may be starting to pay off, as officials announced this week that the numbers of new infections had plateaued and, on Saturday, that ICU cases had gone for the first time.
That glimmer of hope has turned the conversation to the daunting challenge of when and how to reopen without setting off another cataclysmic wave of contagion. To do so, Italian health officials and some politicians have focused on an idea that might once have been relegated to the realm of dystopian novels and science fiction films.That glimmer of hope has turned the conversation to the daunting challenge of when and how to reopen without setting off another cataclysmic wave of contagion. To do so, Italian health officials and some politicians have focused on an idea that might once have been relegated to the realm of dystopian novels and science fiction films.
Having the right antibodies to the virus in one’s blood — a potential marker of immunity — may soon determine who gets to work and who does not, who is locked down and who is free.Having the right antibodies to the virus in one’s blood — a potential marker of immunity — may soon determine who gets to work and who does not, who is locked down and who is free.
That debate is in some ways ahead of the science. Researchers are uncertain, if hopeful, that antibodies in fact indicate immunity. But that has not stopped politicians from grasping at the idea as they come under increasing pressure to open economies and avoid inducing a widespread economic depression.That debate is in some ways ahead of the science. Researchers are uncertain, if hopeful, that antibodies in fact indicate immunity. But that has not stopped politicians from grasping at the idea as they come under increasing pressure to open economies and avoid inducing a widespread economic depression.
An experimental vaccine is ready to test in people as soon as the Food and Drug Administration grants permission, researchers at the University of Pittsburgh Medical Center said.An experimental vaccine is ready to test in people as soon as the Food and Drug Administration grants permission, researchers at the University of Pittsburgh Medical Center said.
Mice given the vaccine produced high levels of antibodies against the new coronavirus. But only clinical trials can determine whether it will be safe and effective in humans.Mice given the vaccine produced high levels of antibodies against the new coronavirus. But only clinical trials can determine whether it will be safe and effective in humans.
“Testing in patients would typically require at least a year and probably longer,” Dr. Louis D. Falo Jr., a member of the research team, said. “This particular situation is different from anything we’ve ever seen, so we don’t know how long the clinical development process will take. Recently announced revisions to the normal processes suggest we may be able to advance this faster.”“Testing in patients would typically require at least a year and probably longer,” Dr. Louis D. Falo Jr., a member of the research team, said. “This particular situation is different from anything we’ve ever seen, so we don’t know how long the clinical development process will take. Recently announced revisions to the normal processes suggest we may be able to advance this faster.”
Another vaccine, made by Moderna, is already in a clinical trial, which started March 15. Dozens more candidates are being developed by other companies.Another vaccine, made by Moderna, is already in a clinical trial, which started March 15. Dozens more candidates are being developed by other companies.
The University of Pittsburgh’s vaccine will be given in an unusual way: through a small patch dotted with 400 “microneedles” made of sugar mixed with a coronavirus protein. The microneedles penetrate the skin and the sugar melts, releasing the full protein dose in 10 minutes or less, and alerting the immune system to start making antibodies to fight the virus.The University of Pittsburgh’s vaccine will be given in an unusual way: through a small patch dotted with 400 “microneedles” made of sugar mixed with a coronavirus protein. The microneedles penetrate the skin and the sugar melts, releasing the full protein dose in 10 minutes or less, and alerting the immune system to start making antibodies to fight the virus.
“It’s not painful,” Dr. Falo said in an interview. “The needles don’t reach any nerves, nor do they reach blood vessels. They’re a little more than half a millimeter long, and the width of a human hair.”“It’s not painful,” Dr. Falo said in an interview. “The needles don’t reach any nerves, nor do they reach blood vessels. They’re a little more than half a millimeter long, and the width of a human hair.”
This approach takes advantage of the skin’s ability to set off a powerful immune response. Skin is the body’s first line of defense against a constant bombardment of bacteria and viruses from the environment, and it is teeming with cells that act like scouts for the immune system, looking for things that shouldn’t be there.This approach takes advantage of the skin’s ability to set off a powerful immune response. Skin is the body’s first line of defense against a constant bombardment of bacteria and viruses from the environment, and it is teeming with cells that act like scouts for the immune system, looking for things that shouldn’t be there.
A vaccination with microneedles uses a smaller dose than the usual shot in the arm requires, allowing more people to be immunized, Dr. Falo said. The vaccine, unlike most, does not have to be frozen or refrigerated, making shipping and storage easier and cheaper.A vaccination with microneedles uses a smaller dose than the usual shot in the arm requires, allowing more people to be immunized, Dr. Falo said. The vaccine, unlike most, does not have to be frozen or refrigerated, making shipping and storage easier and cheaper.
A report on the research was published in EBioMedicine.A report on the research was published in EBioMedicine.
“Once we have been given approval, we will be ready to go” with testing, Dr. Falo said.“Once we have been given approval, we will be ready to go” with testing, Dr. Falo said.
A meeting planned for Monday between officials of the Organization of the Petroleum Exporting Countries, Russia and other oil producers, which had buoyed hopes for a deal to end the turmoil in energy markets, has been put off, according to two OPEC delegates.A meeting planned for Monday between officials of the Organization of the Petroleum Exporting Countries, Russia and other oil producers, which had buoyed hopes for a deal to end the turmoil in energy markets, has been put off, according to two OPEC delegates.
The news comes as lingering tensions have resurfaced between Saudi Arabia, OPEC’s de facto leader, and Russia over who is to blame for the recent collapse in oil prices. On Friday, President Vladimir V. Putin of Russia partly blamed Saudi Arabia for the price drop; the Saudi ministers of foreign affairs and energy then responded angrily, blaming Russia.The news comes as lingering tensions have resurfaced between Saudi Arabia, OPEC’s de facto leader, and Russia over who is to blame for the recent collapse in oil prices. On Friday, President Vladimir V. Putin of Russia partly blamed Saudi Arabia for the price drop; the Saudi ministers of foreign affairs and energy then responded angrily, blaming Russia.
News of the meeting’s delay may roil the markets when trading resumes on Monday. Expectations for a meeting had added to hopes that OPEC and Russia would agree on production trims.News of the meeting’s delay may roil the markets when trading resumes on Monday. Expectations for a meeting had added to hopes that OPEC and Russia would agree on production trims.
The OPEC delegates indicated that further talks would be required before moving ahead with a meeting, which could be rescheduled for later in the week. Saudi Arabia had called for the meeting last Thursday, responding to pressure from President Trump.The OPEC delegates indicated that further talks would be required before moving ahead with a meeting, which could be rescheduled for later in the week. Saudi Arabia had called for the meeting last Thursday, responding to pressure from President Trump.
In early March, Russia declined to go along with a Saudi-led OPEC proposal to further trim production to deal with the plummeting demand for oil because of the coronavirus epidemic, leading the Saudis to walk away from a three-year agreement with Moscow on production trims.In early March, Russia declined to go along with a Saudi-led OPEC proposal to further trim production to deal with the plummeting demand for oil because of the coronavirus epidemic, leading the Saudis to walk away from a three-year agreement with Moscow on production trims.
The Trump administration is using a Korean War-era law to redirect to the United States surgical masks manufactured by 3M in other countries as part of a heated pressure campaign to force the Minnesota company to cut off sales of surgical masks abroad.The Trump administration is using a Korean War-era law to redirect to the United States surgical masks manufactured by 3M in other countries as part of a heated pressure campaign to force the Minnesota company to cut off sales of surgical masks abroad.
The policy, embodied in an executive order the Trump administration issued on Friday evening, is a significant expansion of the American government’s reach. It is also a reversal of President Trump’s hesitant use of the Defense Production Act, which allows the administration to force a company to prioritize the U.S. government over competing orders.The policy, embodied in an executive order the Trump administration issued on Friday evening, is a significant expansion of the American government’s reach. It is also a reversal of President Trump’s hesitant use of the Defense Production Act, which allows the administration to force a company to prioritize the U.S. government over competing orders.
But in this case, the administration is invoking the law to compel 3M to send the masks it makes in factories overseas to the United States, and to stop exporting U.S.-made masks. Those moves, some trade and legal experts fear, could backfire, possibly prompting foreign governments to clamp down on the flow of desperately needed medical necessities to the United States.But in this case, the administration is invoking the law to compel 3M to send the masks it makes in factories overseas to the United States, and to stop exporting U.S.-made masks. Those moves, some trade and legal experts fear, could backfire, possibly prompting foreign governments to clamp down on the flow of desperately needed medical necessities to the United States.
The Trump administration’s new executive order directs federal emergency management and health officials to use the law’s authority to preserve respirators, surgical masks and surgical gloves for domestic use.The Trump administration’s new executive order directs federal emergency management and health officials to use the law’s authority to preserve respirators, surgical masks and surgical gloves for domestic use.
Since the 1960s War on Poverty, a network of community health clinics around the nation have served as a health care refuge for people with no health insurance and few financial resources. But the effects of the coronavirus pandemic have left many of these clinics in dire financial straits.Since the 1960s War on Poverty, a network of community health clinics around the nation have served as a health care refuge for people with no health insurance and few financial resources. But the effects of the coronavirus pandemic have left many of these clinics in dire financial straits.
Around the country, nonprofit community health centers provide primary care to about 29 million people regardless of their ability to pay. But now they are laying off workers and cutting back in-person appointments because of a loss of revenues from the kinds of procedures that usually bring in money, such as dental work — all now canceled with the need for social distancing.Around the country, nonprofit community health centers provide primary care to about 29 million people regardless of their ability to pay. But now they are laying off workers and cutting back in-person appointments because of a loss of revenues from the kinds of procedures that usually bring in money, such as dental work — all now canceled with the need for social distancing.
One clinic in rural Washington State has laid off more than a third of its work force. A network of clinics in the Boston area has cut back a fourth of its staff.One clinic in rural Washington State has laid off more than a third of its work force. A network of clinics in the Boston area has cut back a fourth of its staff.
“I worry a lot,” said Chuck Jones, the chief executive of the Boston-area clinics, Harbor Health Services, “that if community health centers go away, we won’t as a society hear the struggles of these people.”“I worry a lot,” said Chuck Jones, the chief executive of the Boston-area clinics, Harbor Health Services, “that if community health centers go away, we won’t as a society hear the struggles of these people.”
The United States was crippled by the brutal flu that swept through the country in the midst of World War I, but nowhere was hit more forcefully than the powerhouse industrial cities of Pennsylvania.The United States was crippled by the brutal flu that swept through the country in the midst of World War I, but nowhere was hit more forcefully than the powerhouse industrial cities of Pennsylvania.
In Philadelphia alone, 20,000 people died — 7,500 in the first six months, 4,500 in one week and 837 in a single day. And then, as now, holding large public events in defiance of scientific advice to stay at home had shattering consequences.In Philadelphia alone, 20,000 people died — 7,500 in the first six months, 4,500 in one week and 837 in a single day. And then, as now, holding large public events in defiance of scientific advice to stay at home had shattering consequences.
Our reporters looked back at how the 1918 flu claimed lives, overwhelmed health care workers and morticians, and prompted ordinary people to rise to the moment in the fight against an invisible foe.Our reporters looked back at how the 1918 flu claimed lives, overwhelmed health care workers and morticians, and prompted ordinary people to rise to the moment in the fight against an invisible foe.
By the end of last week, coronavirus cases in Philadelphia had reached 2,430, with 26 deaths. And officials there were scrambling to secure the needed equipment, including ventilators.By the end of last week, coronavirus cases in Philadelphia had reached 2,430, with 26 deaths. And officials there were scrambling to secure the needed equipment, including ventilators.
But memories of the 1918 epidemic had already prompted an aggressive response from Philadelphia’s public health authorities. One result: Unlike some American cities, they expect to have enough hospital beds to withstand even a worst-case scenario.But memories of the 1918 epidemic had already prompted an aggressive response from Philadelphia’s public health authorities. One result: Unlike some American cities, they expect to have enough hospital beds to withstand even a worst-case scenario.
“The state has handled it very differently, and the city handled it radically differently,” said Dr. Tony S. Reed, chief medical officer at Temple University Hospital. “Frankly, for us it’s going to make all the difference in the world.”“The state has handled it very differently, and the city handled it radically differently,” said Dr. Tony S. Reed, chief medical officer at Temple University Hospital. “Frankly, for us it’s going to make all the difference in the world.”
The Chinese government held a nationwide day of mourning on Saturday, the day of the annual Tomb Sweeping Festival, a traditional time for honoring ancestors. Flags flew at half-staff, and alarms and horns sounded for three minutes starting at 10 a.m. Xi Jinping and other leaders of the ruling Communist Party attended a ceremony in Beijing.The Chinese government held a nationwide day of mourning on Saturday, the day of the annual Tomb Sweeping Festival, a traditional time for honoring ancestors. Flags flew at half-staff, and alarms and horns sounded for three minutes starting at 10 a.m. Xi Jinping and other leaders of the ruling Communist Party attended a ceremony in Beijing.
It will probably not be enough to soothe many families in the city of Wuhan, who have chafed against the state’s efforts to assert control over the grieving process.It will probably not be enough to soothe many families in the city of Wuhan, who have chafed against the state’s efforts to assert control over the grieving process.
Officials are pushing relatives to bury their dead quickly and quietly, and they are suppressing online discussion of fatalities as doubts emerge about the true size of China’s toll from the virus. If China’s tallies are vastly understated, as the C.I.A. has been warning the White House since at least early February, predictive modeling for the United States and other countries would be thrown off, or robbed of a major pool of data.Officials are pushing relatives to bury their dead quickly and quietly, and they are suppressing online discussion of fatalities as doubts emerge about the true size of China’s toll from the virus. If China’s tallies are vastly understated, as the C.I.A. has been warning the White House since at least early February, predictive modeling for the United States and other countries would be thrown off, or robbed of a major pool of data.
The police in Wuhan, where the pandemic began, have been dispatched to break up groups on WeChat, a popular messaging app, set up by relatives of coronavirus victims. Government censors have scrubbed social media of images that showed relatives lining up at Wuhan funeral homes to collect ashes. Officials have assigned minders to relatives to follow them as they pick burial plots, claim their loved ones’ remains and bury them, grieving family members say.The police in Wuhan, where the pandemic began, have been dispatched to break up groups on WeChat, a popular messaging app, set up by relatives of coronavirus victims. Government censors have scrubbed social media of images that showed relatives lining up at Wuhan funeral homes to collect ashes. Officials have assigned minders to relatives to follow them as they pick burial plots, claim their loved ones’ remains and bury them, grieving family members say.
Liu Pei’en, whose father died after contracting the coronavirus in a Wuhan hospital, said officials had insisted on accompanying him to a funeral home to pick up his father’s remains. Later, they followed him to the cemetery where they watched him bury his father, he said. Mr. Liu saw one of his minders take photos of the funeral, which was over in 20 minutes.Liu Pei’en, whose father died after contracting the coronavirus in a Wuhan hospital, said officials had insisted on accompanying him to a funeral home to pick up his father’s remains. Later, they followed him to the cemetery where they watched him bury his father, he said. Mr. Liu saw one of his minders take photos of the funeral, which was over in 20 minutes.
“My father devoted his whole life to serving the country and the party,” Mr. Liu, 44, who works in finance, said by phone. “Only to be surveilled after his death.”“My father devoted his whole life to serving the country and the party,” Mr. Liu, 44, who works in finance, said by phone. “Only to be surveilled after his death.”
A leading researcher who fought a different virus; a prodigious songwriter still in his prime; the first black president of the Marseille soccer club; a jazz patriarch.A leading researcher who fought a different virus; a prodigious songwriter still in his prime; the first black president of the Marseille soccer club; a jazz patriarch.
They are among those who died this week from Covid-19, and were profiled in our series about people lost to the pandemic.They are among those who died this week from Covid-19, and were profiled in our series about people lost to the pandemic.
Gita Ramjee: In South Africa, Dr. Gita Ramjee led AIDS studies and drug trials, hoping to overcome not only H.I.V. but also cultural barriers to stopping its spread. On Tuesday, another epidemic claimed her: She died of Covid-19 at a Durban hospital. She had fallen ill shortly after returning from a visit to her sons in London, local news accounts said. She was 63.Gita Ramjee: In South Africa, Dr. Gita Ramjee led AIDS studies and drug trials, hoping to overcome not only H.I.V. but also cultural barriers to stopping its spread. On Tuesday, another epidemic claimed her: She died of Covid-19 at a Durban hospital. She had fallen ill shortly after returning from a visit to her sons in London, local news accounts said. She was 63.
Adam Schlesinger: He made suburban characters shine for the band Fountains of Wayne and brought pop-rock perfection to the film “That Thing You Do!” Adam Schlesinger, an acclaimed performer who had an award-winning second career writing songs for film, theater and television, died on Wednesday at 52.Adam Schlesinger: He made suburban characters shine for the band Fountains of Wayne and brought pop-rock perfection to the film “That Thing You Do!” Adam Schlesinger, an acclaimed performer who had an award-winning second career writing songs for film, theater and television, died on Wednesday at 52.
Pape Diouf: Mababa “Pape” Diouf, who became the only black president of a top-tier European soccer club when he was appointed to lead France’s Olympique de Marseille, died at 68 on Tuesday. He was a gifted orator and a defender of the club’s passionate fan base.Pape Diouf: Mababa “Pape” Diouf, who became the only black president of a top-tier European soccer club when he was appointed to lead France’s Olympique de Marseille, died at 68 on Tuesday. He was a gifted orator and a defender of the club’s passionate fan base.
Ellis Marsalis: His sons Wynton and Branford gained national fame embodying a fresh-faced revival of traditional jazz. But Ellis Marsalis had been an influential musician and teacher in New Orleans long before that. He died on Wednesday at 85.Ellis Marsalis: His sons Wynton and Branford gained national fame embodying a fresh-faced revival of traditional jazz. But Ellis Marsalis had been an influential musician and teacher in New Orleans long before that. He died on Wednesday at 85.
Reporting was contributed by Alan Blinder, Denise Grady, Michael Ives, Raphael Minder, Jason Horowitz, Elian Peltier, Nada Hussein, Constant Méheut, Christopher F. Schuetze, Katrin Bennhold, Yonette Joseph, Elaina Plott, Dan Barry, Caitlin Dickerson, Alisha Haridasani Gupta, Thomas Gibbons-Neff, Eric Schmitt, Matthew Haag, Peter Eavis, Niraj Chokshi, David Gelles, Christopher Flavelle, Zolan Kanno-Youngs, Nicholas Bogel-Burroughs, Alan Feuer, Helene Cooper, Katie Benner, Alan Rappeport, Michael D. Shear, Sheila Kaplan, Sarah Mervosh, Jack Healy, Amy Qin, Cao Li, Yiwei Wang, Albee Zhang, Alexandra Stevenson, Steve Eder, Henry Fountain, Michael H. Keller and Muyi Xiao.Reporting was contributed by Alan Blinder, Denise Grady, Michael Ives, Raphael Minder, Jason Horowitz, Elian Peltier, Nada Hussein, Constant Méheut, Christopher F. Schuetze, Katrin Bennhold, Yonette Joseph, Elaina Plott, Dan Barry, Caitlin Dickerson, Alisha Haridasani Gupta, Thomas Gibbons-Neff, Eric Schmitt, Matthew Haag, Peter Eavis, Niraj Chokshi, David Gelles, Christopher Flavelle, Zolan Kanno-Youngs, Nicholas Bogel-Burroughs, Alan Feuer, Helene Cooper, Katie Benner, Alan Rappeport, Michael D. Shear, Sheila Kaplan, Sarah Mervosh, Jack Healy, Amy Qin, Cao Li, Yiwei Wang, Albee Zhang, Alexandra Stevenson, Steve Eder, Henry Fountain, Michael H. Keller and Muyi Xiao.