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| Nobel prize in medicine awarded to hypoxia researchers – as it happened | Nobel prize in medicine awarded to hypoxia researchers – as it happened |
| (32 minutes later) | |
| So there we have it, this year’s Nobel prize in physiology or medicine goes to a trio of scientists for their work in unpicking how cells sense and respond to changes in oxygen levels. | |
| Check out Ian Sample’s news story here: (he’s just been on the phone to the newly minted laureate Sir Peter Ratcliffe). | |
| Nobel prize in medicine awarded to hypoxia researchers | |
| And don’t forget to join us tomorrow for the Nobel prize in physics from 10:15am! | |
| Prof Bridget Lumb, president of the Physiological Society, has released her thoughts – again stressing how this year’s prize is really a celebration of a fundamental biological mechanism. | |
| “This year’s Nobel prize puts physiology front and centre. It shines a light on the vital research carried out by physiologists,” she said.“Cutting edge physiological research such as this is improving our understanding of how our bodies work and thereby helping keep us healthy. | |
| “Thanks to this research we know much more about how different levels of oxygen impact on physiological processes in our bodies. This has huge implications for everything from recovery from injury and protection from disease, through to improving exercise performance.” | “Thanks to this research we know much more about how different levels of oxygen impact on physiological processes in our bodies. This has huge implications for everything from recovery from injury and protection from disease, through to improving exercise performance.” |
| Kaelin’s thoughts on receiving the call have come out – apparently he was speaking to AP. | |
| “I was aware as a scientist that if you get a phone call at 5am with too many digits, it’s sometimes very good news, and my heart started racing. It was all a bit surreal,” he said. | |
| Hellmut Augustin, director of the European Centre for Angioscience, is very excited about today’s prize, saying it has been awarded for the discovery of a very fundamental mechanism of life. | |
| “The hypoxia program controls the expression of hundreds of molecules. Among the more prominently oxygen regulated molecules are the master switch of blood vessel growth VEGF (vascular endothelial growth factor) and the key regulator of erythrocyte [red blood cell] production, erythropoietin,” he said. | |
| “Hypoxia regulation of gene expression governs all kind of biological processes and diseases ranging from the retinopathy of prematurity in newborns, to the growth of blood vessels in tumours to high altitude training of athletes,” he added. | “Hypoxia regulation of gene expression governs all kind of biological processes and diseases ranging from the retinopathy of prematurity in newborns, to the growth of blood vessels in tumours to high altitude training of athletes,” he added. |
| Nobel selfies seem to be a new thing. | Nobel selfies seem to be a new thing. |
| Congratulations to 2019 Medicine Laureate William Kaelin!Kaelin was alone at home when the call came from Stockholm but sent us this selfie after the #NobelPrize announcement. pic.twitter.com/LRu3D5f29U | Congratulations to 2019 Medicine Laureate William Kaelin!Kaelin was alone at home when the call came from Stockholm but sent us this selfie after the #NobelPrize announcement. pic.twitter.com/LRu3D5f29U |
| More reaction – this time from Dr Alex Greenhough at the University of the West of England who works on cancer biology. | More reaction – this time from Dr Alex Greenhough at the University of the West of England who works on cancer biology. |
| “The work by Ratcliffe, Kaelin and Semenza has been crucial to our understanding of how cells sense and respond to changes in oxygen levels,” he said. “Their work is of huge significance to diseases that feature an impaired blood supply, which includes important solid tumours such as breast, colorectal and pancreatic cancers. Their outstanding work on the fundamental mechanisms of oxygen sensing will pave the way for future therapies that will be able to exploit the disease-specific nature of hypoxia for clinical benefit” | “The work by Ratcliffe, Kaelin and Semenza has been crucial to our understanding of how cells sense and respond to changes in oxygen levels,” he said. “Their work is of huge significance to diseases that feature an impaired blood supply, which includes important solid tumours such as breast, colorectal and pancreatic cancers. Their outstanding work on the fundamental mechanisms of oxygen sensing will pave the way for future therapies that will be able to exploit the disease-specific nature of hypoxia for clinical benefit” |
| Just in case you feel that Gregg Semenza has been left out of the proceedings on the blog, here is a picture of him post-win. | Just in case you feel that Gregg Semenza has been left out of the proceedings on the blog, here is a picture of him post-win. |
| https://twitter.com/NobelPrize/status/1181159403409612801 | https://twitter.com/NobelPrize/status/1181159403409612801 |
| Ian Sample has a news story up already on this year’s prize – take a look here. We will be adding further details and reaction to the award as it comes in. | Ian Sample has a news story up already on this year’s prize – take a look here. We will be adding further details and reaction to the award as it comes in. |
| Nobel prize in medicine awarded to hypoxia researchers | Nobel prize in medicine awarded to hypoxia researchers |
| Reaction to this year’s award is coming in. Dr Andrew Murray from the department of physiology, development and neuroscience at the University of Cambridge, said the award was richly deserved and offered the trio his congratulations. | Reaction to this year’s award is coming in. Dr Andrew Murray from the department of physiology, development and neuroscience at the University of Cambridge, said the award was richly deserved and offered the trio his congratulations. |
| “Oxygen is fundamental to animal life, allowing our mitochondria to extract energy from the food we eat. The work of Kaelin, Ratcliffe and Semenza revealed the elegant mechanisms by which our cells sense oxygen levels and respond to fluctuations, enhancing the delivery of oxygen to the tissues of the body and altering our metabolism,” he said. | “Oxygen is fundamental to animal life, allowing our mitochondria to extract energy from the food we eat. The work of Kaelin, Ratcliffe and Semenza revealed the elegant mechanisms by which our cells sense oxygen levels and respond to fluctuations, enhancing the delivery of oxygen to the tissues of the body and altering our metabolism,” he said. |
| “Since the first reports of the hypoxia inducible factors appeared in the early 1990s, we have come to realise the vital role they play in our everyday physiology, in allowing humans to live at high altitude and in countless biomedical scenarios. Hypoxia (a low tissue oxygen content) is a feature of many diseases including heart failure, chronic lung disease and many cancers. The work of these three scientists and their teams has paved the way to a greater understanding of these common, life-threatening conditions and new strategies to treat them.” | “Since the first reports of the hypoxia inducible factors appeared in the early 1990s, we have come to realise the vital role they play in our everyday physiology, in allowing humans to live at high altitude and in countless biomedical scenarios. Hypoxia (a low tissue oxygen content) is a feature of many diseases including heart failure, chronic lung disease and many cancers. The work of these three scientists and their teams has paved the way to a greater understanding of these common, life-threatening conditions and new strategies to treat them.” |
| Some have noted that, once again, all the winners are male. Only 12 women have been awarded the prize since the awards began. The last woman to win the award was Tu Youyou in 2015. | Some have noted that, once again, all the winners are male. Only 12 women have been awarded the prize since the awards began. The last woman to win the award was Tu Youyou in 2015. |
| Sir Peter Ratcliffe appears to be taking the win in his stride. | Sir Peter Ratcliffe appears to be taking the win in his stride. |
| “Grant proposal deadlines wait for no-one!"Sir Peter Ratcliffe sitting at his desk working on his EU Synergy Grant application, after learning he had been awarded this year's Nobel Prize in Physiology or Medicine.Photographer: Catherine King pic.twitter.com/np0ty6SLi9 | “Grant proposal deadlines wait for no-one!"Sir Peter Ratcliffe sitting at his desk working on his EU Synergy Grant application, after learning he had been awarded this year's Nobel Prize in Physiology or Medicine.Photographer: Catherine King pic.twitter.com/np0ty6SLi9 |
| My colleague Ian Sample previously covered the 2016 Lasker prize: here is his piece on Ratcliffe’s work on how cells adapt to changes in oxygen levels. As Ian notes “The discovery has already led to a raft of experimental anaemia drugs that trick the body into thinking it is at high altitude, causing it to churn out more red blood cells.” | My colleague Ian Sample previously covered the 2016 Lasker prize: here is his piece on Ratcliffe’s work on how cells adapt to changes in oxygen levels. As Ian notes “The discovery has already led to a raft of experimental anaemia drugs that trick the body into thinking it is at high altitude, causing it to churn out more red blood cells.” |
| Oxford biologist Sir Peter Ratcliffe wins Lasker research award | Oxford biologist Sir Peter Ratcliffe wins Lasker research award |
| The Crick is rather happy... | The Crick is rather happy... |
| We're delighted that our Director of Clinical Research, Peter Ratcliffe, has won the @NobelPrize in Physiology or Medicine! Congratulations to Peter, @DanaFarber’s William Kaelin and @JohnsHopkins’ Gregg Semenza! https://t.co/0XQIEmWHmQ | We're delighted that our Director of Clinical Research, Peter Ratcliffe, has won the @NobelPrize in Physiology or Medicine! Congratulations to Peter, @DanaFarber’s William Kaelin and @JohnsHopkins’ Gregg Semenza! https://t.co/0XQIEmWHmQ |
| On winning the Lasker award for his work that has today been celebrated with a Nobel prize, William Kaelin noted the papers behind the discovery were published more than a decade ago. “Most would be considered quaint, preliminary and barely publishable today,” he wrote. “One — showing that a tumour-suppressor protein was required for oxygen signalling — would today be criticized for failing to include a clear mechanism and animal experiments.” | On winning the Lasker award for his work that has today been celebrated with a Nobel prize, William Kaelin noted the papers behind the discovery were published more than a decade ago. “Most would be considered quaint, preliminary and barely publishable today,” he wrote. “One — showing that a tumour-suppressor protein was required for oxygen signalling — would today be criticized for failing to include a clear mechanism and animal experiments.” |