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Frog skin diabetes treatment hope Frog skin diabetes treatment hope
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Skin secretions from a South American "shrinking" frog could be used to treat type 2 diabetes, researchers say.Skin secretions from a South American "shrinking" frog could be used to treat type 2 diabetes, researchers say.
A compound isolated from the frog, which unusually starts life as a 27cm tadpole before shrinking to 4cm in adulthood, stimulates insulin release. A compound isolated from the frog, which grows to 27cm as a tadpole before shrinking to 4cm in adulthood, stimulates insulin release.
A synthetic version of the compound - pseudin-2 - could be used to produce new drugs, delegates at the Diabetes UK annual conference heard.A synthetic version of the compound - pseudin-2 - could be used to produce new drugs, delegates at the Diabetes UK annual conference heard.
Around two million people in the UK have type 2 diabetes.Around two million people in the UK have type 2 diabetes.
The condition, which is often associated with being overweight, develops because the body does not produce enough insulin, or when the insulin that is produced does not work properly.The condition, which is often associated with being overweight, develops because the body does not produce enough insulin, or when the insulin that is produced does not work properly.
It means people cannot regulate their blood glucose levels properly.It means people cannot regulate their blood glucose levels properly.
Scientists from the University of Ulster and United Arab Emirates University have tested a synthetic version of pseudin-2, a compound which protects the paradoxical frog from infection.Scientists from the University of Ulster and United Arab Emirates University have tested a synthetic version of pseudin-2, a compound which protects the paradoxical frog from infection.
More research is needed, but there is a growing body of work around natural anti-diabetic drug discovery that, as you can see, is already yielding fascinating results Dr Yasser Abdel-WahabMore research is needed, but there is a growing body of work around natural anti-diabetic drug discovery that, as you can see, is already yielding fascinating results Dr Yasser Abdel-Wahab
They found it stimulated the secretion of insulin in pancreatic cells in the laboratory.They found it stimulated the secretion of insulin in pancreatic cells in the laboratory.
And importantly, there were no toxic effects on the cells.And importantly, there were no toxic effects on the cells.
The synthetic version was better at stimulating insulin than the natural compound, opening the way for it potential development as a drug for treating diabetes.The synthetic version was better at stimulating insulin than the natural compound, opening the way for it potential development as a drug for treating diabetes.
AmphibiansAmphibians
Study leader Dr Yasser Abdel-Wahab, senior lecturer in biomedical sciences at the University of Ulster, said there had been a lot of research into bioactive molecules from amphibian skin secretions.Study leader Dr Yasser Abdel-Wahab, senior lecturer in biomedical sciences at the University of Ulster, said there had been a lot of research into bioactive molecules from amphibian skin secretions.
One recently developed diabetes drug - exenatide - was developed from a hormone in the saliva of the Gila monster - a lizard found in south-western United States and northern Mexico.One recently developed diabetes drug - exenatide - was developed from a hormone in the saliva of the Gila monster - a lizard found in south-western United States and northern Mexico.
"We found that it stimulated the secretion of insulin and that the synthetic version is more potent that pseudin-2 itself."We found that it stimulated the secretion of insulin and that the synthetic version is more potent that pseudin-2 itself.
"More research is needed, but there is a growing body of work around natural anti-diabetic drug discovery that, as you can see, is already yielding fascinating results.""More research is needed, but there is a growing body of work around natural anti-diabetic drug discovery that, as you can see, is already yielding fascinating results."
Douglas Smallwood, chief executive of Diabetes UK, said although type 2 diabetes could be managed with diet and physical activity, the condition was progressive and may require medication to control it effectively.Douglas Smallwood, chief executive of Diabetes UK, said although type 2 diabetes could be managed with diet and physical activity, the condition was progressive and may require medication to control it effectively.
"Good diabetes control reduces the risk of complications including blindness, heart disease, kidney problems and amputation so new treatments are vital.""Good diabetes control reduces the risk of complications including blindness, heart disease, kidney problems and amputation so new treatments are vital."